TY - JOUR T1 - Effects of acute salbutamol intake during supramaximal exercise in women JF - British Journal of Sports Medicine JO - Br J Sports Med SP - 430 LP - 434 DO - 10.1136/bjsm.2006.033845 VL - 41 IS - 7 AU - Bénédicte Le Panse AU - Alexandre Arlettaz AU - Hugues Portier AU - Anne-Marie Lecoq AU - Jacques De Ceaurriz AU - Katia Collomp Y1 - 2007/07/01 UR - http://bjsm.bmj.com/content/41/7/430.abstract N2 - Objective: To study the effects of an acute therapeutic oral intake of β2 agonist on performance and substrate response during supramaximal exercise in women. Methods: 12 healthy moderately trained female volunteers performed a Wingate test after ingestion of placebo (Pla) and salbutamol (Sal; 4 mg) according to a double-blind randomised crossover study. Blood samples were collected at rest, at the end of exercise and after 5 (r5), 10 (r10) and 15 (r15) min of passive recovery for adrenocorticotropic hormone (ACTH), growth hormone (GH), insulin, blood glucose and lactate measurements. Results: Peak power (PP) and mean power (MP) significantly increased whereas time to peak power was significantly shorter with Sal than with Pla (p<0.05). No change was observed in the fatigue index. ACTH was not significantly modified but r15 growth hormone significantly decreased (p<0.05) after the intake of Sal. Both blood INS and blood glucose were significantly increased by the intake of Sal during all the experiments (p<0.01). Blood lactate was significantly increased by the intake of Sal compared with that of Pla (p<0.05) after 10 and 15 min of passive recovery. Conclusion: From these data, acute therapeutic oral intake of Sal seems to induce, irrespective of the subjects’ gender, an improvement in performance during a supramaximal exercise—that is, increase in PP and MP. Further studies are necessary to clarify whether the mechanisms involved in the response to intake of Sal are linked to central and/or peripheral pathways. ER -