RT Journal Article
SR Electronic
T1 Tissue engineering for tendon repair
JF British Journal of Sports Medicine
JO Br J Sports Med
FD BMJ Publishing Group Ltd and British Association of Sport and Exercise Medicine
SP e10
OP e10
DO 10.1136/bjsm.2006.030643
VO 41
IS 8
A1 Pierre-Olivier Bagnaninchi
A1 Ying Yang
A1 Alicia J El Haj
A1 Nicola Maffulli
YR 2007
UL http://bjsm.bmj.com/content/41/8/e10.abstract
AB Tissue engineering aims to induce tissue self-regeneration in vivo or to produce a functional tissue replacement in vitro to be then implanted in the body. To produce a viable and functional tendon, a uniaxially orientated collagen type I matrix has to be generated. Biochemical and physical factors can potentially alter both the production and the organisation of this matrix, and their combination in a dose- and time-dependent manner is probably the key to in vitro engineered tendons. This review discusses the role of these different factors affecting tenocyte growth in a three-dimensional environment in vivo and in vitro, and underlines the future challenge of tendon tissue engineering.