PT - JOURNAL ARTICLE AU - Yamamoto, Y AU - Nakaji, S AU - Umeda, T AU - Matsuzaka, M AU - Takahashi, I AU - Tanabe, M AU - Danjo, K AU - Kojima, A AU - Oyama, T TI - Effects of long-term training on neutrophil function in male university judoists AID - 10.1136/bjsm.2007.032011 DP - 2008 Apr 01 TA - British Journal of Sports Medicine PG - 255--259 VI - 42 IP - 4 4099 - http://bjsm.bmj.com/content/42/4/255.short 4100 - http://bjsm.bmj.com/content/42/4/255.full SO - Br J Sports Med2008 Apr 01; 42 AB - Objectives: To clarify the effects of high-intensity and high-frequency long-term/chronic training on neutrophil function and serum levels of myogenic enzymes in male university judoists.Methods: The subjects were 24 male judoists who had stopped judo training for 6 months and then restarted their training. The following parameters were examined before and after a 2 h unified exercise loading (UEL) at the beginning of the restarted quotidian training (pre-training) and at 2 months, 4 months and 6 months thereafter: myogenic enzymes, neutrophil and leucocyte counts, and neutrophil phagocytic activity (PA) and oxidative burst activity as a measure of reactive oxygen species (ROS) production capability.Results: Myogenic enzymes that were measured after UEL at all four points significantly increased except for creatine kinase at the 2-month point (p<0.01 in each) and neutrophil counts significantly increased after UEL at the pre-training, 2-month and 4-month points (p<0.01 in each), but these changes became smaller from the 2-month point. PA significantly decreased after UEL at the pre-training and 2-month points (p<0.01 in each), but no change was seen at the 4-month and 6-month points. On the other hand, no change in ROS production per cell after UEL was seen at the pre-training point, but it significantly increased after UEL at the 2-month, 4-month and 6-month points (p<0.01 in each).Conclusion: The changing rate of the levels of UEL-mediated myogenic enzymes, neutrophil mobilisation and neutrophil function was seen to decrease at the 2-month, 4-month and 6-month assessments, compared with the pre-training point: these may comprise at least some of the long-term training effects.