PT - JOURNAL ARTICLE AU - Malcolm Collins AU - Michael Posthumus AU - Martin P Schwellnus TI - The <em>COL1A1</em> gene and acute soft tissue ruptures AID - 10.1136/bjsm.2008.056184 DP - 2010 Nov 01 TA - British Journal of Sports Medicine PG - 1063--1064 VI - 44 IP - 14 4099 - http://bjsm.bmj.com/content/44/14/1063.short 4100 - http://bjsm.bmj.com/content/44/14/1063.full SO - Br J Sports Med2010 Nov 01; 44 AB - Three studies have suggested that the rare TT genotype of the functional Sp1 binding site polymorphism within intron 1 of COL1A1 is associated with cruciate ligament ruptures (CL), shoulder dislocations (SD) and/or Achilles tendon ruptures. Similar genotype distributions were reported for the control and the injury groups in all three studies. In this report, the data from these studies were combined and analyzed. The TT genotype, when compared to the control group (4.1%, n=24 of 581), was significantly under-represented in the (1) CL (0.3%, n=1 of 350, OR=15.0, P=0.0002), (2) CL and SD (0.4% TT genotype, n=2 of 476, OR=10.2, P&lt;0.0001), and (3) CL, SD and Achilles tendon ruptures (0.4% TT genotype, n=2 of 517, OR=11.1, P&lt;0.0001) groups. This combined analysis indicates that the TT genotype appears to be protective against acute soft tissue ruptures and should be incorporated into multifactorial models determining risk of acute soft tissue ruptures.