PT  - JOURNAL ARTICLE
AU  - Mahenderan Appukutty
AU  - Ammu Radhakrishnan
AU  - Kalavathy Ramasamy
AU  - Abu Bakar Abdul Majeed
AU  - Karuthan Chinna
AU  - Ismail Mohd Noor
AU  - Nik Shanita Safii
AU  - Poh Bee Koon
TI  - Salivary immunoglobulin A (sIgA) responses to bovine colostrum supplementation during regular training in physically active young healthy adolescents
AID  - 10.1136/bjsm.2010.078725.145
DP  - 2010 Sep 01
TA  - British Journal of Sports Medicine
PG  - i44--i44
VI  - 44
IP  - Suppl 1
4099  - http://bjsm.bmj.com/content/44/Suppl_1/i44.1.short
4100  - http://bjsm.bmj.com/content/44/Suppl_1/i44.1.full
SO  - Br J Sports Med2010 Sep 01; 44
AB  - Immunoglobulin (Ig) is an essential soluble mediator of humoral immunity to prevent infectious agents that invades the host. Secretory IgA is the main effecter in mucosal immunity and acts as a first line of defence in the host immunity system. Exercise is known to modulate the production of specific antibody and it is anticipated that dietary intervention such as bovine colostrum may modulate the mucosal immunity. The purpose of this study was to investigate the effect of nutritional supplementation of bovine colostrum on salivary immunoglobulin A (sIgA). The subjects comprise adolescent school boys from Bukit Jalil Sports School that are actively involved on regular physical training. The subjects were randomly assigned into experimental (colostrum; n=20) or control (skimmed milk; n=20) group. The experimental and control groups were not significantly different in terms of age and body mass index. The former consumed 20 g of bovine colostrum supplement, and the latter 20 g of skimmed milk, daily for 6 weeks. sIgA measurement was conducted pre- (day 0) and post-supplementation (day 42). Bovine colostrum supplementation significantly increase saliva IgA (p<0.001) in the experimental group as compared to the control group. It was concluded that 6 weeks of bovine colostrum supplementation increases sIgA concentration in active young adolescents during training. Further studies are needed to investigate the mechanistic basis of sIgA and colostrum interaction.