RT Journal Article
SR Electronic
T1 Androgen receptor gene polymorphisms lean mass and performance in young men
JF British Journal of Sports Medicine
JO Br J Sports Med
FD BMJ Publishing Group Ltd and British Association of Sport and Exercise Medicine
SP 95
OP 100
DO 10.1136/bjsm.2009.060285
VO 45
IS 2
A1 Amelia Guadalupe-Grau
A1 F Germán Rodríguez-González
A1 Cecilia Dorado
A1 Hugo Olmedillas
A1 Teresa Fuentes
A1 Jorge Pérez-Gómez
A1 Safira Delgado-Guerra
A1 Germán Vicente-Rodríguez
A1 Ignacio Ara
A1 Borja Guerra
A1 Rafael Arteaga-Ortiz
A1 José A L Calbet
A1 B Nicolás Díaz-Chico
YR 2011
UL http://bjsm.bmj.com/content/45/2/95.abstract
AB The exon-1 of the androgen receptor (AR) gene contains two repeat length polymorphisms which modify either the amount of AR protein inside the cell (GGNn, polyglycine) or its transcriptional activity (CAGn, polyglutamine). Shorter CAG and/or GGN repeats provide stronger androgen signalling and vice versa. To test the hypothesis that CAG and GGN repeat AR polymorphisms affect muscle mass and various variables of muscular strength phenotype traits, the length of CAG and GGN repeats was determined by PCR and fragment analysis and confirmed by DNA sequencing of selected samples in 282 men (28.6±7.6 years). Individuals were grouped as CAG short (CAGS) if harbouring repeat lengths of ≤21 and CAG long (CAGL) if CAG >21. GGN was considered short (GGNS) or long (GGNL) if GGN ≤23 or >23, respectively. No significant differences in lean body mass or fitness were observed between the CAGS and CAGL groups, or between GGNS and GGNL groups, but a trend for a correlation was found for the GGN repeat and lean mass of the extremities (r=−0.11, p=0.06). In summary, the lengths of CAG and GGN repeat of the AR gene do not appear to influence lean mass or fitness in young men.