RT Journal Article
SR Electronic
T1 THYROID HORMONES RECEPTORS ARE PRESENT AND EFFECTIVE ON HEALTHY AND RUPTURED ROTATOR CUFF TENDONS. A PRELIMINARY REPORT
JF British Journal of Sports Medicine
JO Br J Sports Med
FD BMJ Publishing Group Ltd and British Association of Sport and Exercise Medicine
SP e3
OP e3
DO 10.1136/bjsports-2013-092558.14
VO 47
IS 10
A1 Francesco Oliva
YR 2013
UL http://bjsm.bmj.com/content/47/10/e3.6.abstract
AB Thyroid hormones (THs), T3 and T4, play an essential role in the development and metabolism of many tissues and organs, and have profound metabolic effects in adult life. Thyroid hormone receptors (TRs) seem to be ubiquitous, but, to our knowledge, their presence in tenocytes has not been investigated. We therefore evaluated the expression pattern of TRs isoforms in three groups of patients: one with rotator cuff tendons tears and with thyroid diseases, one with rotator cuff tendons tears without thyroid diseases, and one with healthy rotator cuff tendons and no thyroid disease. In addition, we evaluated the action of THs on growth and apoptosis of primary tenocyte cultures. The α/β nuclear receptor isoforms are present in healthy and pathologic rotator cuff tendons. THs enhance the growth and counteract apoptosis in primary tenocyte cultures in a dose and time dependent manner.