PT - JOURNAL ARTICLE AU - Close, Graeme L AU - Leckey, Jill AU - Patterson, Marcelle AU - Bradley, Warren AU - Owens, Daniel J AU - Fraser, William D AU - Morton, James P TI - The effects of vitamin D<sub>3</sub> supplementation on serum total 25[OH]D concentration and physical performance: a randomised dose–response study AID - 10.1136/bjsports-2012-091735 DP - 2013 Jul 01 TA - British Journal of Sports Medicine PG - 692--696 VI - 47 IP - 11 4099 - http://bjsm.bmj.com/content/47/11/692.short 4100 - http://bjsm.bmj.com/content/47/11/692.full SO - Br J Sports Med2013 Jul 01; 47 AB - Background Vitamin D deficiency is common in the general public and athletic populations and may impair skeletal muscle function. We therefore assessed the effects of vitamin D3 supplementation on serum 25[OH]D concentrations and physical performance. Methods 30 club-level athletes were block randomised (using baseline 25[OH]D concentrations) into one of three groups receiving either a placebo (PLB), 20 000 or 40 000 IU/week oral vitamin D3 for 12 weeks. Serum 25[OH]D and muscle function (1-RM bench press and leg press and vertical jump height) were measured presupplementation, 6 and 12 weeks postsupplementation. Vitamin D deficiency was defined in accordance with the US Institute of Medicine guideline (&lt;50 nmol/l). Results 57% of the subject population were vitamin D deficient at baseline (mean±SD value 51±24 nmol/l). Following 6 and 12 weeks supplementation with 20 000 IU (79±14 and 85±10 nmol/l, respectively) or 40 000 IU vitamin D3 (98±14 and 91±24 nmol/l, respectively), serum vitamin D concentrations increased in all participants, with every individual achieving concentrations greater than 50 nmol/l. In contrast, vitamin D concentration in the PLB group decreased at 6 and 12 weeks (37±18 and 41±22 nmol/l, respectively). Increasing serum 25[OH]D had no significant effect on any physical performance parameter (p&gt;0.05). Conclusions Both 20 000 and 40 000 IU vitamin D3 supplementation over a 6-week period elevates serum 25[OH]D concentrations above 50 nmol/l, but neither dose given for 12 weeks improved our chosen measures of physical performance.