PT - JOURNAL ARTICLE AU - Olalekan A Uthman AU - Danielle A van der Windt AU - Joanne L Jordan AU - Krysia S Dziedzic AU - Emma L Healey AU - George M Peat AU - Nadine E Foster TI - Exercise for lower limb osteoarthritis: systematic review incorporating trial sequential analysis and network meta-analysis AID - 10.1136/bjsports-2014-5555rep DP - 2014 Nov 01 TA - British Journal of Sports Medicine PG - 1579--1579 VI - 48 IP - 21 4099 - http://bjsm.bmj.com/content/48/21/1579.short 4100 - http://bjsm.bmj.com/content/48/21/1579.full SO - Br J Sports Med2014 Nov 01; 48 AB - STUDY QUESTION Which types of exercise intervention are most effective in relieving pain and improving function in people with lower limb osteoarthritis? SUMMARY ANSWER As of 2002 sufficient evidence had accumulated to show significant benefit of exercise over no exercise. An approach combining exercises to increase strength, flexibility, and aerobic capacity is most likely to be effective for relieving pain and improving function. WHAT IS KNOWN AND WHAT THIS PAPER ADDS Current international guidelines recommend therapeutic exercise (land or water based) as “core” and effective management of osteoarthritis. Evidence from this first network meta-analysis, largely based on studies in knee osteoarthritis, indicates that an intervention combining strengthening exercises with flexibility and aerobic exercise is most likely to improve outcomes of pain and function. Further trials of exercise versus no exercise are unlikely to overturn this positive result.