PT  - JOURNAL ARTICLE
AU  - Andrew J Gardner
AU  - Can Ozan Tan
AU  - Philip N Ainslie
AU  - Paul van Donkelaar
AU  - Peter Stanwell
AU  - Christopher R Levi
AU  - Grant L Iverson
TI  - Cerebrovascular reactivity assessed by transcranial Doppler ultrasound in sport-related concussion: a systematic review
AID  - 10.1136/bjsports-2014-093901
DP  - 2015 Aug 01
TA  - British Journal of Sports Medicine
PG  - 1050--1055
VI  - 49
IP  - 16
4099  - http://bjsm.bmj.com/content/49/16/1050.short
4100  - http://bjsm.bmj.com/content/49/16/1050.full
SO  - Br J Sports Med2015 Aug 01; 49
AB  - Background Traumatic brain injury influences regulation of cerebral blood flow in animal models and in human studies. We reviewed the use of transcranial Doppler ultrasound (US) to monitor cerebrovascular reactivity following sport-related concussion.Review method A narrative and systematic review of articles published in the English language, from December 1982 to October 2013.Data sources Articles were retrieved via numerous databases using relevant key terms. Observational, cohort, correlational, cross-sectional and longitudinal studies were included.Results Three publications met the criteria for inclusion; these provided data from 42 athletes and 33 controls. All three studies reported reductions in cerebrovascular reactivity via transcranial Doppler US.Conclusions These initial results support the use of cerebrovascular reactivity as a research tool for identifying altered neurophysiology and monitoring recovery in adult athletes. Larger cross-sectional, prospective and longitudinal studies are required to understand the sensitivity and prognostic value of cerebrovascular reactivity in sport-related concussion.