Number of comparisons | LTPA (MET-h/wk) | Pfor non-linearity | ||||||
---|---|---|---|---|---|---|---|---|
0 | 10 | 20 | 40 | 60 | 80 | |||
Overall | 69 | 1.00 | 0.93 (0.91 to 0.95) | 0.91 (0.88 to 0.93) | 0.90 (0.88 to 0.91) | 0.89 (0.87 to 0.92) | 0.89 (0.85 to 0.94) | 0.000 |
Sex | ||||||||
Male | 10 | 1.00 | 0.97 (0.92 to 1.02) | 0.94 (0.90 to 0.98) | 0.92 (0.88 to 0.97) | 0.93 (0.87 to 1.02) | – | 0.25 |
Female | 41 | 1.00 | 0.95 (0.93 to 0.98) | 0.95 (0.92 to 0.97) | 0.93 (0.90 to 0.95) | 0.89 (0.85 to 0.93) | 0.86 (0.79 to 0.93) | 0.10 |
Location | ||||||||
America | 39 | 1.00 | 0.92 (0.90 to 0.95) | 0.89 (0.87 to 0.92) | 0.87 (0.84 to 0.90) | 0.86 (0.81 to 0.91) | 0.85 (0.77 to 0.93) | 0.0001 |
Europe | 17 | 1.00 | 0.95 (0.90 to 1.00) | 0.94 (0.90 to 0.97) | 0.93 (0.89 to 0.97) | – | – | 0.18 |
Asia | 8 | 1.00 | 0.90 (0.87 to 0.93) | 0.89 (0.86 to 0.92) | 0.90 (0.86 to 0.96) | 0.91 (0.86 to 0.96) | – | 0.000 |
Cancer types | ||||||||
Breast cancer | 19 | 1.00 | 0.96 (0.94 to 0.99) | 0.95 (0.93 to 0.98) | 0.93 (0.90 to 0.96) | 0.90 (0.86 to 0.95) | 0.88 (0.81 to 0.95) | 0.41 |
Colorectal cancer | 10 | 1.00 | 0.92 (0.85 to 1.00) | 0.85 (0.79 to 0.92) | 0.86 (0.80 to 0.94) | – | – | 0.002 |
Endometrial cancer | 5 | 1.00 | 1.03 (0.93 to 1.15) | 0.97 (0.87 to 1.08) | 0.91 (0.81 to 1.02) | – | – | 0.46 |
Pancreatic cancer | 5 | 1.00 | 0.94 (0.77 to 1.14) | 0.90 (0.73 to 1.09) | 0.87 (0.73 to 1.05) | 0.88 (0.69 to 1.12) | – | 0.72 |
Ovarian cancer | 4 | 1.00 | 0.89 (0.75 to 1.05) | 0.91 (0.76 to 1.08) | 0.99 (0.81 to 1.22) | 0.97 (0.76 to 1.26) | 0.91 (0.68 to 1.23) | 0.28 |
Age at measurement | ||||||||
≥50 | 21 | 1.00 | 0.96 (0.92 to 1.01) | 0.94 (0.91 to 0.99) | 0.93 (0.89 to 0.97) | 0.92 (0.85 to 0.99) | 0.92 (0.82 to 1.03) | 0.36 |
Quality of study | ||||||||
≥7 | 68 | 1.00 | 0.94 (0.92 to 0.96) | 0.93 (0.91 to 0.94) | 0.91 (0.90 to 0.93) | 0.90 (0.88 to 0.93) | 0.88 (0.85 to 0.93) | 0.000 |
Follow-up (years) | ||||||||
≥10 | 32 | 1.00 | 0.95 (0.92 to 0.98) | 0.94 (0.92 to 0.97) | 0.93 (0.90 to 0.95) | 0.90 (0.86 to 0.94) | – | 0.14 |
<10 | 37 | 1.00 | 0.93 (0.91 to 0.96) | 0.91 (0.89 to 0.93) | 0.90 (0.88 to 0.93) | 0.90 (0.87 to 0.93) | 0.89 (0.84 to 0.95) | 0.00 |
Moderate-to-vigorous LTPA | 40 | 1.00 | 0.94 (0.92 to 0.97) | 0.91 (0.89 to 0.93) | 0.88 (0.86 to 0.90) | 0.88 (0.84 to 0.91) | 0.87 (0.83 to 0.93) | 0.0001 |
LTPA, leisure time physical activity; MET-h/wk, metabolic equivalents of energy hours per week.