Table 3

Results of the unadjusted and adjusted Cox regression models for the variables tested

Indicator	Unit/qualifier	Unadjusted model			Adjusted model
	Unit/qualifier	HR	95% CI	p Value	HR	95% CI
Main exposure of interest
Shoe version	Standard shoes is ref	0.59*	0.39 to 0.91	0.016†	0.55*	0.36 to 0.85
Participants’ characteristics
Age	Years	0.99	0.97 to 1.01	0.150†	0.99	0.97 to 1.02
Sex	Male is ref	1.02	0.67 to 1.54	0.944
BMI	1 kg/m² increase	1.07*	1.01 to 1.15	0.034†	1.05	0.98 to 1.12
Previous injury	No (previous injury) is ref	2.77*	1.82 to 4.21	<0.001†	2.70*	1.77 to 4.11
Running experience	Years	0.99	0.97 to 1.02	0.527
Regularity (last 12 months)	Months	0.90*	0.82 to 0.99	0.028†	0.91	0.83 to 1.01
Foot morphology	Neutral is ref
	Supinated (and highly)	1.27	0.72 to 2.24	0.405†	1.42	0.80 to 2.54
	Pronated (and highly)	1.34	0.84 to 2.15	0.225†	1.43	0.88 to 2.30
Sport participation pattern
Other sports frequency	Sessions/week	1.04	0.91 to 1.18	0.617
Running frequency	Sessions/week	0.78	0.61 to 1.01	0.057†	0.82	0.62 to 1.08
Mean session duration	min	1.00	0.99 to 1.01	0.974
Mean session distance	km	0.90*	0.83 to 0.98	0.014†	0.93	0.86 to 1.02
Mean session intensity	au	0.91	0.73 to 1.14	0.424

*Significant results.
†Variables with p value <0.200 or used for the stratified randomisation were included in the adjusted model; total volume of exposure: 12 094 h; au, arbitrary unit; BMI, body mass index. ‡Years of regular practice of running.