Selected adjuvant medications for neuropathic and nociplastic/algopathic/nocipathic pain in adults*
| First-line medications | Total daily dose and dose regimen |
| Anticonvulsants | |
| Gabapentin | Begin at 100–300 mg 1–3×/day; may be increased to 1200–3600 mg/day in three divided doses |
| Pregabalin | Begin at 25 to 75 mg 1–2×/day; may be increased up to a dose of 150–600 mg/day in divided doses |
| Antidepressants | |
| Serotonin–noradrenaline reuptake inhibitors: duloxetine | Begin at 20 to 30 mg 1×/day; may be increased up to 120 mg 1×/day |
| Serotonin–noradrenaline reuptake inhibitors: venlafaxine ER | Begin at 37.5–75 mg 1×/day; may be increased to 225 mg 1×/day or in divided doses |
| Tricyclic: amitriptyline or nortriptyline | Begin at 10–20 mg at night; may be increased to 150 mg at night |