Table 4

Selected adjuvant medications for neuropathic and nociplastic/algopathic/nocipathic pain in adults*

First-line medicationsTotal daily dose and dose regimen
GabapentinBegin at 100–300 mg 1–3×/day; may be increased to 1200–3600 mg/day in three divided doses
PregabalinBegin at 25 to 75 mg 1–2×/day; may be increased up to a dose of 150–600 mg/day in divided doses
Serotonin–noradrenaline reuptake inhibitors: duloxetineBegin at 20 to 30 mg 1×/day; may be increased up to 120 mg 1×/day
Serotonin–noradrenaline reuptake inhibitors: venlafaxine ERBegin at 37.5–75 mg 1×/day; may be increased to 225 mg 1×/day or in divided doses
Tricyclic: amitriptyline or nortriptylineBegin at 10–20 mg at night; may be increased to 150 mg at night