Outcome data from included prospective cohort studies for: study name; participant number and age range; years of follow-up; serum cholesterol, total fat and saturated fat for CHD-free versus CHD deaths22 24 25 or CHD-free versus development of CHD;4 20 21 and other significant associations found
| Study | Men/Age | CHD-free? | Follow-up years | Deaths All-cause/CHD | Cholesterol CHD/Non | Total fat CHD/Non | Sat fat CHD/Non | Other Significant associations with CHD |
|---|---|---|---|---|---|---|---|---|
| Western Electric Study21 | 1989 (40–55) | Y | 4 | 38/13 | CHD/Non 272/247 mean mg/dL | CHD/Non 148/152 g/day* | CHD/Non 59/59 g/day* | Age of death of father, smoking, coffee, elevated blood pressure |
| Seven Countries Study4 Note 1 | 12 770 (40–59) | 98% | 5 | 588/158 | r=0.76 | r=0.40* | r=0.84 | Previous MI. NO association found with CHD and activity, smoking or weight |
| The following data were available to the UK Committee only: | ||||||||
| London Bank and Bus study20 | 337 (30–67) | Y | 20 | 51/26 | Note 2 3-5.6 mmol/l 7 deaths 5.6-6.5 mmmol/l 13 deaths 6.5-8.6 mmol/l 16 deaths | Note 3* 30–39% 18 38–43% 10 41–56% 17 | NA | Age of participant. Smoking. Higher calorie intake/cereal fibre and lower CHD |
| Framingham19 24 | 859 (45–64) | Y | 4 | 47/14 | NA | CHD death/alive 112/114 g/day* | CHD death/alive 46/44 g/day* | Higher calorie intake and lower CHD. Higher alcohol intake and lower CHD |
| Honolulu19 25 | 7272 (45–64) | Y | 6 | 395/78 | NA | CHD death/alive 86/87 g/day* | CHD death/alive 32/32 g/day* | Higher calorie intake and lower CHD. Higher starch intake and lower CHD. Higher alcohol intake and lower CHD |
| Puerto Rico19 22 | 8218 (45–64) | Y | 6 | 402/71 | NA | CHD death/alive 94/96 g/day* | CHD death/alive 34/36 g/day* | Higher calorie intake and lower CHD. Rural living and lower CHD |
| Total (6 studies) | 31 445 | 1521/360 | ||||||
Note 1: The Pearson correlation coefficients presented in this row represent 13 cohorts (both Japanese and the Rome railroad cohorts were missing). The coefficients represent the relationship between serum cholesterol, total dietary fat and saturated fat intake for the 13 cohorts and CHD deaths and infarctions. Data for CHD deaths alone were not presented. Data for men without heart disease on entry were not available. The data did not compare fat/cholesterol of those with CHD versus those without. The correlations apply to fat/cholesterol data for cohorts relative to each other.
Note 2: Tertiles of cholesterol in mmol/l and number of CHD cases, not deaths, in each tertile.
Note 3: Percentage of dietary intake accounted for by total fat and number of CHD cases, not deaths, in each tertile.
*Not statistically significant.
CHD, coronary heart disease; MI, myocardial infarction; NA, data not available.