Table 2

Six-month and 12-month changes in DXA bone parameters in completers randomised to the PATCH, PILL or NONE (controlled for age, height, race and ethnicity)

	PATCH	PILL	NONE	P (whole model)	PATCH versus PILL	PATCH versus NONE	PILL versus NONE
6-month changes in bone parameters	n=27	n=28	n=30
Δ Lumbar spine BMC (g)	1.456±0.813	−0.239±0.806	0.106±0.866	0.003*	0.001*	0.007*	0.465
Δ Lumbar BMD (g/cm²)	0.025±0.011	0.008±0.011	0.012±0.012	0.039*	0.014*	0.060†	0.489
Δ Lumbar BMD Z-score	0.219±0.107	0.033±0.106	0.058±0.114	0.010*	0.005*	0.013*	0.689
Δ Femoral neck BMC (g)	0.207±0.118	0.155±0.117	0.106±0.125	0.369	0.475	0.160	0.478
Δ Femoral neck BMD (g/cm²)	0.027±0.014	0.002±0.014	0.013±0.015	0.020*	0.005*	0.092	0.206
Δ Femoral neck BMD Z-score	0.234±0.131	0.019±0.129	0.110±0.139	0.028*	0.008*	0.111	0.223
Δ Total hip BMC (g)	0.276±0.506	−0.385±0.502	−0.279±0.539	0.082	0.036*	0.071†	0.719
Δ Total hip BMD (g/cm²)	0.017±0.012	−0.002±0.011	0.007±0.012	0.027	0.007*	0.157	0.155
Δ Total hip BMD Z-score	0.094±0.095	−0.062±0.094	0.022±0.101	0.030	0.009*	0.204	0.134
Δ Total body less head BMC (g)	25.95±17.15	3.86±16.99	11.17±18.25	0.110	0.039*	0.155	0.463
Δ Total body less head BMD (g/cm²)	0.010±0.008	0.001±0.008	0.005±0.008	0.137	0.047*	0.278	0.317
12-month changes in bone parameters	n=25	n=22	n=26
Δ Lumbar spine BMC (g)	1.758±0.925	0.008±0.911	−0.189±0.992	0.002*	0.005*	0.001*	0.740
Δ Lumbar BMD (g/cm²)	0.022±0.013	0.001±0.013	−0.003±0.014	0.007*	0.015*	0.003*	0.657
Δ Lumbar BMD Z-score	0.133±0.126	−0.043±0.124	−0.092±0.135	0.014*	0.038*	0.005*	0.557
Δ Femoral neck BMC (g)	0.180±0.112	0.111±0.110	0.098±0.120	0.452	0.342	0.236	0.864
Δ Femoral neck BMD (g/cm²)	0.041±0.017	0.012±0.017	0.015±0.019	0.016*	0.011*	0.015*	0.808
Δ Femoral neck BMD Z-score	0.333±0.164	0.098±0.161	0.084±0.176	0.031*	0.036*	0.016*	0.898
Δ Total hip BMC (g)	−0.386±0.644	−1.277±0.633	−1.243±0.690	0.054†	0.038*	0.034*	0.934
Δ Total hip BMD (g/cm²)	0.0145±0.015	−0.009±0.015	0.000±0.016	0.055†	0.018*	0.123	0.335
Δ Total hip BMD Z-score	0.047±0.131	−0.135±0.129	−0.066±0.141	0.114	0.043†	0.169	0.427
Δ Total body less head BMC (g)	36.08±19.38	12.98±19.08	12.81±20.78	0.0995	0.073†	0.056	0.989
Δ Total body less head BMD (g/cm²)	0.000±0.009	−0.008±0.009	−0.005±0.009	0.364	0.172	0.315	0.663

Mean±SEM.
*P<0.05 after controlling for weight changes over time;.
†P<0.1 after controlling for weight changes over time.
Δ, change; BMD, bone mineral density; BMC, bone mineral content.