Association between leisure time physical activity level and the risk of all-cause and cause-specific mortality by intensity of activity
| Leisure time PA level, minutes/week, HR (95% CI) | ||||||
| 0 | 10–59 | 60– 149 | 150–299 | 300–599 | ≥600 | |
| Light/moderate | ||||||
| Participants (N) | 44 281 | 6384 | 17 797 | 10 395 | 5996 | 3287 |
| All-cause | ||||||
| Deaths (n) | 5074 | 352 | 1041 | 715 | 426 | 247 |
| Model 1 | 1 | 0.75 (0.66 to 0.85) | 0.70 (0.65 to 0.76) | 0.76 (0.69 to 0.83) | 0.69 (0.62 to 0.77) | 0.78 (0.67 to 0.91) |
| Model 2 | 1 | 0.79 (0.69 to 0.89) | 0.75 (0.69 to 0.82) | 0.82 (0.75 to 0.89) | 0.75 (0.67 to 0.83) | 0.81 (0.69 to 0.94) |
| Model 3 | 1 | 0.81 (0.71 to 0.92) | 0.78 (0.72 to 0.85) | 0.84 (0.77 to 0.92) | 0.74 (0.66 to 0.83) | 0.80 (0.68 to 0.93) |
| CVD | ||||||
| Deaths (n) | 1132 | 79 | 199 | 130 | 99 | 56 |
| Model 1 | 1 | 0.79 (0.62 to 1.02) | 0.63 (0.52 to 0.75) | 0.60 (0.48 to 0.75) | 0.70 (0.55 to 0.90) | 0.77 (0.56 to 1.08) |
| Model 2 | 1 | 0.82 (0.64 to 1.06) | 0.69 (0.57 to 0.83) | 0.66 (0.53 to 0.83) | 0.77 (0.60 to 0.99) | 0.81 (0.58 to 1.13) |
| Model 3 | 1 | 0.84 (0.65 to 1.09) | 0.72 (0.59 to 0.86) | 0.69 (0.55 to 0.86) | 0.78 (0.61 to 0.99) | 0.84 (0.60 to 1.16) |
| Cancer | ||||||
| Deaths (n) | 1341 | 105 | 359 | 239 | 153 | 72 |
| Model 1 | 1 | 0.72 (0.57 to 0.91) | 0.78 (0.68 to 0.90) | 0.86 (0.74 to 0.99) | 0.83 (0.70 to 0.99) | 0.73 (0.55 to 0.98) |
| Model 2 | 1 | 0.77 (0.61 to 0.97) | 0.84 (0.73 to 0.97) | 0.94 (0.80 to 1.09) | 0.90 (0.75 to 1.08) | 0.77 (0.57 to 0.99) |
| Model 3 | 1 | 0.79 (0.62 to 0.99) | 0.88 (0.76 to 0.99) | 0.97 (0.83 to 1.13) | 0.89 (0.74 to 1.06) | 0.76 (0.57 to 0.99) |
| Vigorous | ||||||
| Participants(N) | 57 889 | 3843 | 11 772 | 8102 | 4561 | 1973 |
| All-cause | ||||||
| Deaths (n) | 6561 | 172 | 490 | 327 | 207 | 98 |
| Model 1 | 1 | 0.68 (0.57 to 0.80) | 0.68 (0.61 to 0.77) | 0.59 (0.52 to 0.66) | 0.63 (0.54 to 0.74) | 0.57 (0.45 to 0.71) |
| Model 2 | 1 | 0.72 (0.61 to 0.85) | 0.73 (0.65 to 0.82) | 0.63 (0.56 to 0.72) | 0.67 (0.57 to 0.78) | 0.57 (0.46 to 0.72) |
| Model 3 | 1 | 0.74 (0.63 to 0.87) | 0.76 (0.68 to 0.86) | 0.66 (0.59 to 0.75) | 0.69 (0.59 to 0.81) | 0.58 (0.46 to 0.73) |
| CVD | ||||||
| Deaths (n) | 1413 | 31 | 113 | 63 | 52 | 23 |
| Model 1 | 1 | 0.66 (0.45 to 0.98) | 0.80 (0.64 to 0.99) | 0.57 (0.42 to 0.78) | 0.79 (0.58 to 1.07) | 0.64 (0.40 to 1.05) |
| Model 2 | 1 | 0.71 (0.48 to 1.06) | 0.87 (0.68 to 1.09) | 0.63 (0.46 to 0.85) | 0.84 (0.62 to 1.14) | 0.64 (0.40 to 1.05) |
| Model 3 | 1 | 0.74 (0.50 to 1.10) | 0.91 (0.72 to 1.15) | 0.67 (0.49 to 0.91) | 0.88 (0.65 to 1.21) | 0.66 (0.40 to 1.07) |
| Cancer | ||||||
| Deaths (n) | 1782 | 63 | 185 | 127 | 74 | 38 |
| Model 1 | 1 | 0.72 (0.54 to 0.96) | 0.76 (0.63 to 0.92) | 0.67 (0.55 to 0.83) | 0.61 (0.46 to 0.81) | 0.61 (0.42 to 0.89) |
| Model 2 | 1 | 0.76 (0.57 to 1.02) | 0.82 (0.68 to 0.98) | 0.73 (0.59 to 0.90) | 0.65 (0.49 to 0.86) | 0.62 (0.43 to 0.91) |
| Model 3 | 1 | 0.79 (0.59 to 1.05) | 0.86 (0.71 to 1.04) | 0.77 (0.63 to 0.95) | 0.67 (0.51 to 0.89) | 0.61 (0.42 to 0.89) |
Model 1: adjusted for sex, age, race/ethnicity and mutually adjusted for both moderate- and vigorous-intensity activities.
Model 2: Model 1 plus additionally adjusted for education, marital status and mutually adjusted for both moderate- and vigorous-intensity activities.
Model 3: Model 2 plus additionally adjusted for body mass index, smoking, alcohol intake and mutually adjusted for both moderate- and vigorous-intensity activities.
CI, confidence interval; CVD, cardiovascular disease; HR, hazard ratio.