Table 2

Differences in pooled mean costs and effects (95% CI), incremental cost-effectiveness ratios, distribution of incremental cost-effect pairs around the quadrants of the cost-effectiveness planes and percentage of bootstrapped cost-effectiveness pairs located in the non-inferiority region of the cost-effectiveness planes

AnalysisSample sizeOutcome∆C (95% CI)∆E (95% CI)ICERDistribution CE plane (%)
PTAPMPoints€/pointNE*SE†SW‡NW§Non-inferiority region
Main analysis – imputed dataset161158IKDC (range: 0–100)−1803 (−3008 to −838)−4.0 (−8.3 to 0.2)4490.02.597.50.097.3
161158QALYs (range: 0–1)−1803 (−3008 to −838)−0.029 (−0.074 to 0.016)61 5840.09.890.10.089.0
SA1 – complete cases8981IKDC (range: 0–100)−976 (−1365 to −589)−7.0 (−11.5 to 2.5)1390.00.199.90.066.9
8981QALYs (range: 0–1)−976 (−1365 to −589)−0.024 (−0.077 to 0.030)40 6670.018.981.10.088.8
SA2 – human capital approach161158IKDC (range: 0–100)−1866 (−3129 to −871)−4.0 (−8.3 to 0.2)4650.02.597.40.097.3
161158QALYs (range: 0–1)−1866 (−3129 to −871)−0.029 (−0.074 to 0.016)63 7410.09.890.10.089.0
SA3 – healthcare perspective161158IKDC (range: 0–100)−1120 (−1767 to −707)−4.0 (−8.3 to 0.2)2790.02.597.40.097.5
161158QALYs (range: 0–1)−1120 (−1767 to −707)−0.029 (−0.074 to 0.016)38 2690.09.890.20.089.0
SA4 – as-treated analysis
PT (≥16 sessions)
97150IKDC (range: 0–100)−3073 (−4280 to −2150)−3.0 (−7.5 to 1.4)10100.08.491.50.098.6
97150QALYs (range: 0–1)−3073 (−4280 to −2150)0.021 (−0.024 to 0.065)−148,8660.081.618.40.099.9
Delayed APM47150IKDC (range: 0–100)525 (−1312 to 2272)−6.0 (−13.1 to 1.1)−881.82.025.470.843.4
47150QALYs (range: 0–1)525 (−1312 to 2272)−0.108 (−0.185 to −0.032)−48500.00.127.772.17.5
  • *Refers to the NE of the CE plane, indicating that PT is more effective and more costly than APM.

  • †Refers to the SE of the CE plane, indicating that PT is more effective and less costly than APM.

  • ‡Refers to the SW of the CE plane, indicating that PT is less effective and less costly than APM.

  • §Refers to the NW of the CE plane, indicating that PT is less effective and more costly than APM.

  • APM, arthroscopic partial meniscectomy; C, costs; CE plane, cost-effectiveness plane; E, effects; ICER, incremental cost-effectiveness ratio; IKDC, International Knee Documentation Committee;NE, northeast; NW, northwest; PT, physical therapy; QALYs, quality-adjusted life years; SA, sensitivity analysis; SE, southeast; SW, southwest.