Subgroup analyses for colorectal neoplasia (random effect)
| Subgroup | Category | n | RR (95% CI) | Pheterogeneity
(I2 statistics) |
| Sex | Female | 7 | 0.84 (0.77 to 0.91) | 0.15 (36%) |
| Male | 7 | 0.82 (0.75 to 0.89) | 0.64 (0%) | |
| Domains of PA | overall | 9 | 0.82 (0.74 to 0.90) | 0.13 (35%) |
| recreational | 14 | 0.75 (0.68 to 0.82) | 0.01 (52%) | |
| occupational | 2 | 0.49 (0.30 to 0.68) | 0.12 (49%) | |
| Measurement instrument of PA | validated | 7 | 0.74 (0.62 to 0.87) | 0.04 (54%) |
| invalidated | 16 | 0.78 (0.71 to 0.85) | <0.01 (61%) | |
| PA assessment methods | PA energy expenditure | 12 | 0.85 (0.76 to 0.88) | 0.21 (24%) |
| PA duration | 3 | 0.63 (0.48 to 0.78) | 0.91 (0%) | |
| PA frequency | 9 | 0.77 (0.66 to 0.89) | <0.01(75%) | |
| Location | Colon | 10 | 0.79 (0.67 to 0.91) | <0.01 (60%) |
| ā | Rectum | 6 | 0.80 (0.54 to 1.07) | 0.07 (50%) |
| Anatomical subsites | Proximal | 7 | 0.85 (0.67 to 1.02) | 0.06 (51%) |
| Distal | 9 | 0.76 (0.59 to 0.92) | 0.01 (64%) | |
| Rectum | 6 | 0.80 (0.54 to 1.07) | 0.07 50%) | |
| Study design | Cross-sectional | 10 | 0.81 (0.75 to 0.87) | 0.05 (45%) |
| Case-control | 8 | 0.62 (0.53 to 0.70) | 0.42 (2%) | |
| Cohort | 5 | 0.82 (0.69 to 0.95) | 0.14 (43%) | |
| Number of adjustment factors | Upper tertile (10-17) | 7 | 0.83 (0.74 to 0.91) | 0.05 (52%) |
| Intermediate tertile (4-8) | 8 | 0.73 (0.61 to 0.85) | 0.51 (0%) | |
| Lower tertile (0ā3) | 8 | 0.73 (0.63 to 0.82) | <0.01(73%) | |
| Adjustments for family history | No | 15 | 0.77 (0.69 to 0.84) | <0.01 (63%) |
| Yes | 8 | 0.77 (0.66 to 0.88) | 0.04 (52%) | |
| Adjustments for obesity | No | 14 | 0.73 (0.65 to 0.81) | <0.01 (61%) |
| Yes | 9 | 0.83 (0.75 to 0.91) | 0.09 (40%) | |
| Adjustments for smoking and alcohol use | No | 10 | 0.72 (0.63 to 0.82) | 0.01 (57%) |
| Yes | 13 | 0.81 (0.74 to 0.88) | 0.02 (48%) | |
| Adjustments for diet behaviours | No | 16 | 0.75 (0.68 to 0.82) | <0.01 (67%) |
| Yes | 7 | 0.82 (0.72 to 0.92) | 0.25 (23%) | |
| Sample size | nā„3000 | 9 | 0.85 (0.80 to 0.89) | 0.16 (31%) |
| n<3000 | 14 | 0.63 (0.56 to 0.70) | 0.55 (0%) | |
| Study setting | National programme | 8 | 0.84 (0.79 to 0.89) | 0.12 (37%) |
| Multiple centres | 7 | 0.72 (0.56 to 0.88) | 0.28 (19%) | |
| Single hospital/unit | 8 | 0.67 (0.57 to 0.78) | 0.10 (42%) |