Meta-analysis for the associations between sedentary time (% of daily wear time) and all-cause mortality by levels of total physical activity (CPM) and time spent in moderate-to-vigorous-intensity physical activity (MVPA; % of daily wear time) (n=44 370; 3451 (model 1); n=42 420; 3137 (model 2); n=42 203; 3074 (model 3); n=42 303; 2508 (model 4)) (n in each cell refers to number of participants and deaths)
| Low sedentary | Medium sedentary | High sedentary | |
| Model 1* | |||
| Total PA (CPM) | |||
| Low PA | 1 (Ref) (n=122; 10) | 0.65 (0.36 to 1.18) (n=2890; 252) | 1.02 (0.58 to 1.78) (n=11 719; 1906) |
| Medium PA | 1 (Ref) (n=3810; 186) | 0.97 (0.95 to 1.26) (n=8413; 457) | 1.10 (0.71 to 1.70) (n=2589; 145) |
| High PA | 1 (Ref) (n=10 889; 348) | 1.13 (0.90 to 1.41) (n=3509; 128) | 1.55 (0.86 to 2.77) (n=429; 19) |
| MVPA | |||
| Low PA | 1 (Ref) (n=1666; 109) | 0.91 (0.73 to 1.14) (n=3973; 345) | 1.73 (1.32 to 2.27) (n=9102; 1669) |
| Medium PA | 1 (Ref) (n=4860; 184) | 1.08 (0.90 to 1.29) (n=5970; 309) | 1.50 (1.24 to 1.82) (n=3979; 304) |
| High PA | 1 (Ref) (n=8295; 251) | 1.18 (0.90 to 1.56) (n=4869; 183) | 1.61 (1.05 to 2.46) (n=1656; 97) |
| Model 2† | |||
| Total PA (CPM) | |||
| Low PA | 1 (Ref) (n=113; 10) | 0.65 (0.36 to 1.18) (n=2738; 231) | 1.04 (0.58 to 1.85) (n=11 102; 1689) |
| Medium PA | 1 (Ref) (n=3645; 175) | 1.00 (0.74 to 1.34) (n=8100; 430) | 1.08 (0.84 to 1.38) (n=2466; 132) |
| High PA | 1 (Ref) (n=10 484; 329) | 1.20 (0.94 to 1.53) (n=3368; 125) | 1.71 (0.94 to 3.10) (n=404; 16) |
| MVPA | |||
| Low PA | 1 (Ref) (n=1582; 103) | 0.98 (0.78 to 1.23) (n=3774; 319) | 1.86 (1.44 to 2.39) (n=8606; 1471) |
| Medium PA | 1 (Ref) (n=4671; 174) | 1.18 (0.95 to 1.45) (n=5751; 293) | 1.57 (1.28 to 1.91) (n=3787; 281) |
| High PA | 1 (Ref) (n=7989; 237) | 1.31 (1.03 to 1.65) (n=4678; 174) | 1.71 (1.14 to 2.59) (n=1579; 85) |
| Model 3‡ | |||
| Total PA (CPM) | |||
| Low PA | 1 (Ref) (n=112; 10) | 0.69 (0.37 to 1.26) (n=2719; 225) | 1.01 (0.56 to 1.85) (n=11 012; 1644) |
| Medium PA | 1 (Ref) (n=3628; 173) | 1.06 (0.78 to 1.46) (8068; 424) | 1.21 (0.86 to 1.72) (2456; 132) |
| High PA | 1 (Ref) (n=10 446; 327) | 1.19 (0.94 to 1.52) (n=3358; 123) | 1.80 (0.87 to 3.74) (n=404; 16) |
| MVPA | |||
| Low PA | 1 (Ref) (n=1575; 102) | 0.98 (0.77 to 1.25) (n=3746; 310) | 1.72 (1.29 to 2.29) (n=8532; 1428) |
| Medium PA | 1 (Ref) (n=4650; 173) | 1.15 (0.89 to 1.49) (n=5730; 290) | 1.51 (1.23 to 1.86) (n=3766; 279) |
| High PA | 1 (Ref) (n=7961; 235) | 1.20 (0.85 to 1.69) (n=4669; 172) | 1.75 (1.07 to 2.87) (n=1574; 85) |
| Model 4§ | |||
| Total PA (CPM) | |||
| Low PA | 1 (Ref) (n=119; 10) | 0.58 (0.33 to 1.01) (n=2764; 197) | 1.13 (0.68 to 1.94) (n=10 847; 1299) |
| Medium PA | 1 (Ref) (n=3671; 156) | 0.99 (0.72 to 1.35) (n=8084; 348) | 1.05 (0.75 to 1.47) (n=2483; 109) |
| High PA | 1 (Ref) (n=10 524; 268) | 1.22 (0.93 to 1.58) (n=3388; 104) | 2.27 (0.91 to 5.67) (n=423; 17) |
| MVPA | |||
| Low PA | 1 (Ref) (n=1614; 92) | 0.92 (0.70 to 1.20) (n=3785; 265) | 1.56 (1.09 to 2.21) (n=8351; 1129) |
| Medium PA | 1 (Ref) (n=4678; n=146) | 1.19 (0.85 to 1.66) (n=5746; 239) | 1.49 (1.14 to 1.94) (n=3675; 229) |
| High PA | 1 (Ref) (n=8022; 196) | 1.17 (0.83 to 1.65) (n=4705; 145) | 1.67 (0.98 to 2.84) (n=1600; 72) |
*Adjusted for age and sex (when applicable).
†Adjusted for age, sex (when applicable), socioeconomic status and BMI.
‡Adjusted for adjusted for age, sex (when applicable), socioeconomic status, BMI and additional covariates described in online supplemental table 1.
§Model three and excluding deaths within 2 years; boldface indicates significant association (p<0.05).
BMI, body mass index; CPM, counts per minute; MVPA, moderate-to-vigorous intensity physical activity; PA, physical activity.