Independent associations between physical activity, sedentary time and BMI with all-cause mortality
| Multivariable adjusted | Multivariable adjusted, restricted to never smokers | |||
| n (deaths) | HR (95% CI) | n (deaths) | HR (95% CI) | |
| BMI categories | ||||
| Normal weight (18.5–25 kg/m2) | 13 030 (745) | Reference | 6823 (318) | Reference |
| Overweight (25–30 kg/m2) | 13 400 (784) | 0.85 (0.75 to 0.97) | 6548 (315) | 0.91 (0.76 to 1.08) |
| Obesity (≥30 kg/m2) | 8062 (505) | 0.93 (0.82 to 1.07) | 4114 (231) | 1.12 (0.91 to 1.37) |
| Total physical activity | ||||
| T1 (least active) | 11 474 (1230) | Reference | 5603 (508) | Reference |
| T2 | 11 511 (475) | 0.59 (0.52 to 0.67) | 5839 (203) | 0.66 (0.51 to 0.87) |
| T3 | 11 507 (329) | 0.53 (0.42 to 0.66) | 6043 (153) | 0.59 (0.47 to 0.73) |
| Light physical activity | ||||
| T1 (least active) | 11 483 (1112) | Reference | 5760 (470) | Reference |
| T2 | 11 500 (531) | 0.69 (0.62 to 0.77) | 5830 (224) | 0.74 (0.62 to 0.88) |
| T3 | 11 509 (391) | 0.66 (0.54 to 0.82) | 5895 (170) | 0.70 (0.56 to 0.86) |
| Moderate-to-vigorous physical activity | ||||
| T1 (least active) | 11 481 (1206) | Reference | 5527 (491) | Reference |
| T2 | 11 502 (486) | 0.66 (0.58 to 0.74) | 5848 (214) | 0.73 (0.59 to 0.91) |
| T3 | 11 509 (342) | 0.61 (0.47 to 0.80) | 6110 (159) | 0.66 (0.52 to 0.83) |
| Sedentary time | ||||
| T1 (least sedentary) | 11 495 (356) | Reference | 5913 (154) | Reference |
| T2 | 11 505 (535) | 0.94 (0.71 to 1.26) | 5839 (238) | 0.97 (0.67 to 1.40) |
| T3 | 11 492 (1143) | 1.31 (0.87 to 1.96) | 5733 (472) | 1.07 (0.82 to 1.40) |
n=34 492, deaths=2034 in multivariable-adjusted model, n=17 485, deaths=886 in multivariable-adjusted model restricted to never smokers. Analyses are restricted to individuals with >2 years of follow-up and excluding individuals with prevalent cardiovascular disease (CVD) or cancer at baseline. Multivariable adjustment includes age, sex (when applicable), socioeconomic status, smoking and the covariates included in each study’s published final multivariable-adjusted model (see online supplemental eTable 1 for details). Moderate-to-vigorous physical activity is adjusted for sedentary time, light physical activity and sedentary time are adjusted for moderate-to-vigorous physical activity. Physical activity and sedentary time are further adjusted for BMI (continuous form) and BMI is adjusted for moderate-to-vigorous physical activity.
BMI, body mass index.