Table 3

Certainty of evidence (GRADE approach) of individual study outcomes

Outcome (follow-up time point)StudyTotal NInterventionControlEffect size
(95% CI)
Certainty rating
Primary outcomes
Meniscal injuries
(Long-term)
Snoeker et al59121Early reconstructionRehabilitation+optional reconstructionOR
0.85, (0.45 to 1.62)
Low*
Secondary outcomes
Health-related quality of life† (Long-term)Frobell et al55120Early reconstructionRehabilitation+optional reconstructionSMD
−0.14, (−0.50 to 0.21)
Low*
Self-reported return to activity‡ (Short-term)Reijman et al53167Early reconstructionRehabilitation+optional reconstructionSMD −0.34,
(−0.66 to −0.03)
Moderate§
Knee stability
(Medium-term)
Frobell et al54121Early reconstructionRehabilitation+optional reconstructionMD −1.70,
(−2.65 to −0.75)
Moderate*
knee stability
(Long-term)
Tsoukas et al5232Early reconstructionRehabilitation+optional reconstructionMD-3.00,
(−3.27 to −2.73)
Low§
Patello-femoral cartilage thickness
(Medium-term)
Culvenor et al60120Early reconstructionRehabilitation+optional reconstructionMD 76.00, (10.63 to 141.37)Moderate*
Patello-femoral cartilage thickness
(Long-term)
Culvenor et al60120Early reconstructionRehabilitation+optional reconstructionMD 107.00, (17.33 to 196.67)Moderate*
Meniscal surgeries
(Long-term)
Snoeker et al59121Early reconstructionRehabilitation+optional reconstructionOR 0.88,
(0.47 to 1.62)
Low*
Cost-effectiveness
(Medium-term)
Eggerding et al57167Early reconstructionRehabilitation+optional reconstructionMD 0.04, (p=0.18), not cost-effectiveModerate§
Cost-effectiveness
(Long-term)
Kiadaliri et al58120Early reconstructionRehabilitation+optional reconstructionMD 0.13,
(−0.03, 0.29) QALY, not cost-effective
Moderate*
Leg-hop limb symmetry index
(Short-term)
Flosadottir et al5689Early reconstructionRehabilitation+optional reconstructionMD 1.10,
(−2.98 to 5.18)
Low*
Single leg-hop limb symmetry index
(Long-term)
Flosadottir et al5689Early reconstructionRehabilitation+optional reconstructionMD 0.80,
(−4.34 to 5.94)
Low*
  • Negative standardised mean differences indicate the effect favoured the intervention.

  • *Certainty rated down for imprecision.

  • †Certainty rated down for risk of bias.

  • ‡SF-36 (mental subscale) (Frobell et al).

  • §Lysholm Scale (Reijman et al).

  • NA, not applicable.