Table 3

Case definitions and clinical features of acute respiratory infections (ARinf) clinical syndromes in athletes

Main anatomical classificationClinical syndromes of ARinf in athletesCase definitionClinical features/notesRefs
Predominantly upper respiratory tract1. Acute infective rhinitis and/or additional features of rhinosinusitis/rhinopharyngitis
(Also described as the ‘common cold’, ‘Coryza’, or ‘viral upper respiratory infection’)
A clinical presentation characterised by rhinitis (blocked/stuffy nose, runny nose, sneezing, nasal discharge) that may be associated with other symptoms and signs of an upper respiratory infection (sore throat, sinus pressure)
  • Regional symptoms (cough, hoarseness, cervical lymphadenopathy, watery eyes) are uncommon

  • Systemic symptoms (fever, headache, myalgia/arthralgia, malaise) are uncommon and if present, they are mild and transient (<48 hours)

  • Conjunctivitis is more common with adenovirus

34 51 91 118
2. Acute infective rhinosinusitis/rhinopharyngitis with systemic symptoms/signs
(Also described as ‘influenza-like’, or ‘influenza’)
A rapid-onset clinical presentation characterised by:
  • at least one upper/regional respiratory symptom (blocked/stuffy nose, runny nose, sneezing, nasal discharge, sore throat, cough)


AND
  • fever (core temperature >38°C) at least once in a 72 hour period


AND
  • at least one systemic symptom/sign (headache, myalgia/arthralgia, excessive fatigue, malaise)

  • Some case definitions stipulate fever, cough and fatigue as the hallmark features

  • WHO case definition of influenza-like illness: An ARinf with: measured fever of ≥38°C, and cough and onset within the last 10 days

119–126
3. Acute pharyngitis*A clinical presentation that is mainly characterised by a sore throat, with objective evidence of pharyngeal inflammation
  • Clinical features of pharyngitis (erythema, exudate) that may include cervical lymphadenopathy

  • May be associated with systemic symptoms (fever, headache, myalgia/arthralgia, malaise)

  • Aetiology can be viral, bacterial or other pathogens

  • Consider Epstein-Barr virus as a cause in young athletes

34
4. Acute laryngitis/laryngotracheobronchitis (‘croup’)*A clinical presentation that is mainly characterised by hoarseness, sore throat and cough
  • Clinical features of laryngitis (hoarseness, sore/scratchy throat) that may be associated with difficulty in breathing, inspiratory stridor

  • Clinical features of tracheobronchitis (dry cough, wet cough, difficulty in breathing, chest pain/pressure, chest tightness)

  • May be associated with systemic symptoms (fever, headache, myalgia/arthralgia, malaise) but this is uncommon

  • Laryngotracheobronchitis (croup) is more common in children

34
Predominantly lower respiratory tract1. Acute tracheobronchitis*A clinical presentation that is mainly characterised by cough (dry or wet) that may be associated with tracheal tenderness and other chest symptoms
  • Clinical features of tracheobronchitis (dry cough, wet cough, difficulty in breathing, chest pain/pressure, chest tightness, wheeze, tracheal tenderness)

  • May be associated with systemic symptoms (fever, headache, myalgia/arthralgia, malaise)

34
2. Acute bronchitis/bronchiolitis *A clinical presentation that is mainly characterised by cough without evidence of pneumonia
  • Acute bronchitis can occur as a complication of acute rhinitis/rhinosinusitis

  • The aetiology of bronchitis can be viral, bacterial or other pathogens

  • Bronchiolitis is a clinical syndrome in infants that is characterised by upper respiratory symptoms for 2–3 days followed by lower respiratory symptoms such as wheezing and other chest symptoms/signs

  • May be associated with systemic symptoms (fever, headache, myalgia/arthralgia, malaise)

34 127
3. Acute pneumoniaA clinical presentation confirmed by special investigations (eg, chest X-ray) that is mainly characterised by productive cough, difficulty in breathing and pleuritic chest pain, which is associated with fever and other systemic symptoms and signs
  • Systemic symptoms (fever, chills, excessive fatigue, general myalgia/arthralgia, skin rash, abdominal pain, nausea, vomiting, diarrhoea, loss of appetite)

  • Clinical signs include tachycardia, tachypnoea, crackles, rales, tactile fremitus, and egophony

  • Acute pneumonia can occur as a complication of other upper respiratory infections

  • The aetiology of acute pneumonia can be viral, bacterial or other pathogens

  • Acute pneumonia is rare in healthy athletes and more common in immunocompromised individuals and those with co-morbidities

34 128
  • *Can present with or without systemic symptoms/signs.