Table 2

MRI regional volumes by TES status

	TES vs non-TES		TES+E vs non-TES		TES+ME vs non-TES
	Estimate (95% CI)	P value	Estimate (95% CI)	P value	Estimate (95% CI)	P value
Thalamus	366 (−613 to −120)	0.004	−252 (−527 to 22)	0.072	−553 (−874 to −233)	0.0008
Putamen	−120 (−317 to 77)	0.230	57 (−156 to 269)	0.598	−410 (−658 to −163)	0.0013
Hippocampus	−235 (−388 to −82)	0.003	−97 (−262 to 68)	0.245	−460 (−652 to −268)	<0.0001
Lateral ventricle	2706 (311 to 5102)	0.027	230 (−2313 to 2772)	0.859	6778 (3817 to 9740)	<0.0001
Inferior lateral ventricle	161 (−16 to 339)	0.075	−56 (−240 to 127)	0.547	519 (305 to 733)	<0.0001
CC_posterior	−89 (−161 to −16)	0.017	−50 (−131 to 31)	0.225	−152 (−246 to −58)	0.0017
CC_mid posterior	−54 (−104 to −4)	0.035	−56 (−113 to 0)	0.051	−50 (−116 to 16)	0.1355
Left cerebral white matter	−8176 (−14 775 to −1576)	0.016	−4170 (−11 469 to 3129)	0.261	−14 763 (−23 264 to −6263)	0.0008
Right cerebral white matter	−8700 (−15 054 to −2346)	0.008	−5002 (−12 041 to 2037)	0.162	−14 782 (−22 980 to −6583)	0.0005
Cerebral white matter	−16 876 (−29 750 to −4003)	0.011	−9172 (−23 418 to 5074)	0.205	−29 545 (−46 137 to −12 953)	0.0006
Subcortical grey	2390 (−3916 to −865)	0.002	−1020 (−2665 to 625)	0.222	−4644 (−6559 to −2728)	<0.0001
Total grey	−15 531 (−27 808 to −3254)	0.014	−7881 (−21 444 to 5682)	0.253	−28 110 (7987)	0.0006

Volumes of the thalamus, putamen and hippocampus represent average of both hemispheres (in cubic mm). TES+E = TES with executive impairment, TES+ME = TES with both memory and executive impairment.
CC, corpus callosum; TES, traumatic encephalopathy syndrome.