Table 1

Relative risk of mortality and incidence of cardiovascular diseases and cancers at three physical activity levels in relation to 0 mMET-hours/week and respective potential impact fractions

Outcomes4.375 mMET-hours/week8.75 mMET-hours/week17.5 mMET-hours/week
RR (95% CI)PIF (95% CI)RR (95% CI)PIF (95% CI)RR (95% CI)PIF (95% CI)
Mortality
 All-cause mortality0.77
(0.73 to 0.80)		10.11
(8.32 to 11.91)		0.69
(0.65 to 0.73)		15.66
(13.16 to 18.15)		0.66
(0.62 to 0.70)		18.75
(16.09 to 21.39)
 Total CVD0.81
(0.77 to 0.85)		6.02
(4.42 to 7.69)		0.71
(0.66 to 0.77)		12.25
(9.37 to 15.17)		0.65
(0.60 to 0.71)		17.05
(13.92 to 20.19)
 Total cancer0.90
(0.88 to 0.93)		3.68
(2.54 to 4.86)		0.85
(0.81 to 0.89)		7.05
(5.1 to 9.00)		0.82
(0.78 to 0.86)		9.29
(7.36 to 11.22)
CVD incidence (fatal and non-fatal events combined)
 Total CVD0.83
(0.79 to 0.87)		5.29
(3.93 to 6.70)		0.73
(0.69 to 0.79)		10.86
(8.43 to 13.31)		0.67
(0.63 to 0.72)		15.42
(13.01 to 17.85)
 Coronary heart disease0.86
(0.83 to 0.90)		5.51
(3.95 to 7.11)		0.79
(0.74 to 0.84)		10.28
(7.61 to 12.96)		0.74
(0.69 to 0.80)		13.58
(10.51 to 16.64)
 Stroke0.86
(0.83 to 0.90)		5.53
(3.96 to 7.15)		0.80
(0.75 to 0.85)		9.77
(7.31 to 12.24)		0.77
(0.72 to 0.82)		12.37
(9.63 to 15.10)
 Heart failure0.90
(0.85 to 0.96)		2.23
(0.80 to 3.89)		0.84
(0.75 to 0.93)		4.63
(1.90 to 7.66)		0.77
(0.68 to 0.87)		7.86
(4.31 to 11.68)
Cancer incidence (fatal and non-fatal events combined)
 Total cancer0.93
(0.91 to 0.95)		2.53
(1.66 to 3.42)		0.88
(0.85 to 0.92)		5.22
(3.55 to 6.90)		0.85
(0.81 to 0.89)		7.80
(5.65 to 9.93)
 Head and neck0.74
(0.59 to 0.94)		10.59
(2.10 to 19.96)		0.65
(0.46 to 0.91)		17.46
(3.68 to 30.98)		0.63
(0.42 to 0.94)		19.83
(1.23 to 36.55)
 Myeloid leukaemia0.80
(0.66 to 0.97)		4.93
(0.68 to 9.70)		0.75
(0.60 to 0.95)		7.08
(1.65 to 12.94)		0.75
(0.60 to 0.94)		7.57
(2.23 to 13.33)
 Myeloma0.84
(0.74 to 0.95)		3.34
(0.90 to 6.26)		0.75
(0.61 to 0.92)		6.76
(1.90 to 12.09)		0.72
(0.57 to 0.92)		8.30
(1.91 to 14.99)
 Gastric cardia0.86
(0.78 to 0.95)		1.95
(0.58 to 3.68)		0.78
(0.66 to 0.91)		4.77
(1.58 to 8.57)		0.73
(0.60 to 0.88)		6.77
(2.55 to 11.63)
 Lung0.89
(0.87 to 0.92)		4.39
(3.16 to 5.63)		0.84
(0.81 to 0.88)		7.26
(5.10 to 9.40)		0.83
(0.76 to 0.91)		8.54
(3.04 to 13.98)
 Liver0.90
(0.83 to 0.98)		3.49
(0.58 to 6.71)		0.84
(0.73 to 0.96)		6.75
(1.44 to 12.31)		0.78
(0.66 to 0.93)		10.27
(3.26 to 17.31)
 Endometrial0.94
(0.90 to 0.99)		1.10
(0.26 to 2.02)		0.90
(0.84 to 0.97)		2.62
(0.76 to 4.60)		0.87
(0.80 to 0.95)		4.54
(1.88 to 7.28)
 Colon0.96
(0.93 to 0.99)		0.70
(0.11 to 1.33)		0.93
(0.87 to 0.99)		1.69
(0.33 to 3.12)		0.90
(0.84 to 0.97)		2.96
(0.92 to 5.05)
 Breast0.97
(0.96 to 0.99)		0.69
(0.32 to 1.07)		0.95
(0.92 to 0.97)		1.62
(0.79 to 2.46)		0.92
(0.88 to 0.96)		3.23
(1.85 to 4.63)
 Bladder0.93
(0.84 to 1.02)		1.91
(−0.54 to 4.52)		0.90
(0.80 to 1.02)		2.98
(−0.24 to 6.33)		0.90
(0.81 to 1.01)		3.11
(0.02 to 6.35)
 Rectum0.96
(0.92 to 1.01)		0.77
(−0.15 to 1.75)		0.95
(0.88 to 1.02)		1.43
(−0.45 to 3.36)		0.96
(0.88 to 1.04)		0.52
(−1.74 to 2.82)
 Oesophageal0.97
(0.89 to 1.05)		0.68
(−0.95 to 2.68)		0.95
(0.82 to 1.09)		1.38
(−2.06 to 5.32)		0.94
(0.79 to 1.12)		1.57
(−3.05 to 6.67)
 Prostate1.00
(0.99 to 1.02)		−0.10
(−0.48 to 0.29)		1.01
(0.98 to 1.04)		−0.21
(−1.10 to 0.71)		1.01
(0.96 to 1.05)		−0.10
(−1.61 to 1.42)
 Kidney1.02
(0.92 to 1.13)		−0.65
(−3.69 to 2.81)		1.03
(0.89 to 1.19)		−1.23
(−6.39 to 4.34)		1.04
(0.88 to 1.24)		−1.91
(−9.20 to 5.63)

  • CVD, cardiovascular disease; mMET, marginal metabolic equivalent of task; PIF, potential impact fraction; RR, relative risk.