Associations between accelerometer-measured total and intensity-specific physical activity and incident T2D stratified by different levels of genetic risk
| High genetic risk | Intermediate genetic risk | Low genetic risk | ||||
| n with/without incident T2D | HR (95% CI) | n with/without incident T2D | HR (95% CI) | n with/without incident T2D | HR (95% CI) | |
| The total volume of physical activity (mg) | ||||||
| P0–P10 (≤26.1) | 93/1801 | 1.00 (ref.) | 63/1891 | 1.00 (ref.) | 49/2036 | 1.00 (ref.) |
| P10–P50 (26.2–38.0) | 221/7679 | 0.76 (0.59 to 0.97) | 113/7813 | 0.62 (0.45 to 0.86) | 75/7829 | 0.61 (0.42 to 0.89) |
| P50–P90 (38.1–54.3) | 126/7847 | 0.53 (0.40 to 0.70) | 67/7882 | 0.45 (0.32 to 0.65) | 43/7764 | 0.44 (0.29 to 0.68) |
| P90–P100 (>54.3) | 19/1989 | 0.34 (0.21 to 0.57) | 7/1939 | 0.24 (0.11 to 0.54) | 8/1971 | 0.39 (0.18 to 0.85) |
| MVPA (min/day) | ||||||
| P0–P10 (≤5.2) | 95/1908 | 1.00 (ref.) | 61/1923 | 1.00 (ref.) | 37/1927 | 1.00 (ref.) |
| P10–P50 (5.3–25.9) | 224/7720 | 0.64 (0.50 to 0.82) | 114/7809 | 0.55 (0.40 to 0.77) | 80/7787 | 0.64 (0.42 to 0.95) |
| P50–P90 (26.0–68.4) | 118/7719 | 0.38 (0.29 to 0.51) | 65/7913 | 0.35 (0.24 to 0.50) | 54/7838 | 0.52 (0.33 to 0.81) |
| P90–P100 (>68.4) | 22/1969 | 0.30 (0.19 to 0.49) | 10/1880 | 0.23 (0.11 to 0.46) | 4/2048 | 0.16 (0.06 to 0.46) |
| LPA (min/day) | ||||||
| P0–P10 (≤202) | 63/1808 | 1.00 (ref.) | 42/1976 | 1.00 (ref.) | 30/2014 | 1.00 (ref.) |
| P10–P50 (202.1–314) | 194/7696 | 0.84 (0.63 to 1.12) | 112/7794 | 0.83 (0.57 to 1.19) | 73/7878 | 0.75 (0.49 to 1.16) |
| P50–P90 (314.1–444) | 179/7808 | 0.87 (0.64 to 1.16) | 80/7789 | 0.68 (0.46 to 1.01) | 56/7801 | 0.64 (0.40 to 1.02) |
| P90–P100 (>444) | 23/2004 | 0.46 (0.28 to 0.75) | 16/1966 | 0.60 (0.33 to 1.08) | 16/1907 | 0.76 (0.40 to 1.42) |
Effect modification on multiplicative scale total physical activity×PRS: p value=0.343.
Effect modification on multiplicative scale MVPA×PRS: p value=0.671.
Effect modification on multiplicative scale LPA×PRS: p value=0.662.
The analyses were all based on multivariable Cox proportional hazards models adjusted for age as the underlying timescale, gender, total wear time, seasonality, ethnicity, educational attainment, household income, Townsend deprivation index, employment status, assessment centres, smoking status, alcohol consumption, healthy diet score, hypertension, dyslipidaemia, depression, PRS, genotyping array, the first 10 principal components of ancestry, and LPA or MVPA (MVPA and LPA were mutually adjusted, but not for the total volume of PA). Bold face values indicate p<0.05.
LPA, light-intensity physical activity; mg, milligravity; MVPA, moderate-to-vigorous-intensity physical activity; P, percentiles; PA, physical activity; PRS, polygenic risk score; T2D, type 2 diabetes.