Table 1

 List of exclusion criteria

1. Any injury of the ankle that required surgery.
2. Pre-existing ankle trauma.
3. History of allergy to one or more ingredients of Phlogenzym.
4. Use of immune suppressing drugs.
5. Parallel intake of non-steroidal anti-inflammatory drugs or analgesics except paracetamol only during the first two days of study treatment.
6. Known severe congenital or acquired coagulation disturbances.
7. Known renal insufficiency with serum creatinine levels >160 μmol/l.
8. Known severe hepatic insufficiency with either/or/and serum aspartate aminotransferase activity >54 U/l, serum alanine aminotransferase activity >42 U/l.
9. Renal dialysis.
10. Known diabetes mellitus.
11. Known pregnancy, or lactation, or women of childbearing potential without the use of a reliable contraceptive method.
12. Known alcohol and/or drug intoxication.
13. An operation pending which could have limited the possibility to follow up the patient.
14. Mental disorders or mentally unable to follow exactly the trial instructions.
15. Previously enrolled in the same trial.
16. Participation in other clinical trials with an investigational product within the 30 days before the inclusion in this study or participation more than 3 times in other clinical trials with drugs in the 12 months before inclusion.