The main components of the matrix metalloprotease (MMP) family
| Name | Synonym | Degrades | Other actions |
|---|---|---|---|
| MMP1 | Collagenase-1 | Collagens type III (preferentially), I, and II | |
| Interstitial collagenase | Collagens type VII, VIII, and X | ||
| Fibroblast collagenase | |||
| MMP2 | 72 kDa gelatinase A | Gelatin, collagens type IV, V, VII, X, and XI | Synergistic with MMP1 |
| 72 kDa type IV gelatinase | Fibronectin, elastin, proteoglycans | ||
| MMP3 | Stromelysin-1 | Proteoglycans, laminin, fibronectin, gelatin | Broad substrate specificity |
| Transin, proteoglycanase | Collagens III, IV, V, and IX | Activates pro-MMPs | |
| Procollagen activating factor | Core protein of cartilage proteoglycans | ||
| MMP7 | Matrilysin | Gelatin, proteoglycans, fibronectin, elastin, casein | Activates pro-MMP1 |
| Pump-1 | |||
| Small uterine proteinase | |||
| MMP8 | Neutrophil collagenase | Collagens type I (preferentially), II, and III | |
| Aggrecan | |||
| MMP9 | 92 kDa gelatinase-B | Collagens type IV, V, X, XI | |
| 92 kDa type IV gelatinase | Gelatin | ||
| MMP10 | Stromelysin-2 | Gelatin, fibronectin, collagens type III, IV, and V | Activates pro-MMPs |
| Transin-2 | |||
| MMP11 | Stromelysin-3 | Aggrecan, fibronectin, laminin | |
| MMP12 | Macrophage metalloelastase | Elastin, collagen types I and IV, aggrecan, fibronectin, laminin, entactin, gelatin type I, vitronectin, fibrillin | |
| MMP13 | Collagenase-3 | Collagens type II (preferentially), I, and III | |
| Gelatin |