Anorexic premenopausal women: negative effect of oral contraceptives on bone mineral density
| Study design | Reference | No of patients | OC exposure | Measurement of BMD/bone metabolism | Results |
|---|---|---|---|---|---|
| OC, Oral contraceptive; BMD, bone mineral density; AN, anorexia nervosa; DXA, dual energy x ray absorptiometry. | |||||
| Cohort (level 2b) | Kreipe et al79 | 4 women with AN (ages 17–28) | Oestrogen + progestin replacement (n = 2) v control (n = 2) for 6 months | Lumbar spine DXA | 1.9% decrease in BMD in oestrogen-progestin treated group v 1.3% increase in BMD in control group |