Table 12

 Anorexic premenopausal women: negative effect of oral contraceptives on bone mineral density

Study designReferenceNo of patientsOC exposureMeasurement of BMD/bone metabolismResults
OC, Oral contraceptive; BMD, bone mineral density; AN, anorexia nervosa; DXA, dual energy x ray absorptiometry.
Cohort (level 2b)Kreipe et al794 women with AN (ages 17–28)Oestrogen + progestin replacement (n = 2) v control (n = 2) for 6 monthsLumbar spine DXA1.9% decrease in BMD in oestrogen-progestin treated group v 1.3% increase in BMD in control group