Table 1

 Genes upregulated or downregulated in cultured tendon cells following exposure to nitric oxide15

Primary functionGeneEffect on gene regulation
COP, coat protein complex; GTPase, guanosine triphosphatase; IGF, insulin-like growth factor; MET, methionine; PRKA, protein kinase A-anchoring; SMA, smooth muscle actin; TGF, transforming growth factor; TNF, tumour necrosis factor.
ApoptosisImmediate early response 3Up
Jun DUp
COP9 constitutive photomorphogenic homologue subunit 8Up
Growth arrest-specific 2 like 1Down
Cell adhesion/communicationProtocadherin α6Up
Catenin (cadherin-associated protein), δ2Down
Cell cycle controlCell division cycle 34Down
Cell growth and/or maintenancePotassium inwardly rectifying channel, subfamily J, member 8Up
Translocated promoter region (to activated MET)Up
Human cellular proto-oncogene (c-mer)Down
TGF-β inducible early proteinDown
S100 calcium-binding protein A11Up
Extracellular matrix/regulationMatrix metalloproteinase 10 (stromelysin 2)Down
Collagen type I, α1Down
DecorinDown
Laminin B2Down
BiglycanDown
Collagen type III, α1Down
Collagen type IV, α5Up
Microfibrillar-associated protein 3-likeUp
Oxidative stress resistanceOxidation resistance 1Up
Signal transductionTNF receptor-associated factor 5Up
Rho GTPase-activating protein 4Up
Interleukin 18 receptor 1Up
IGF-II mRNA-binding protein 3Up
SMA D5Up
Phospholipase D1, phophatidylcholine-specificUp
Tyrosine 3-mono-oxygenase/tryptophan 5-mono-oxygenase activation protein, ζpolypeptideUp
Ras suppressor protein 1Up
Interferon regulatory factor 3Up
A kinase (PRKA) anchor protein 10Up
Mitogen-activated protein kinase 7Down
Transport, cell growth and/or maintenanceSolute carrier family 22Up