Table 2 Baseline characteristics of the study population by intervention group (n = 152)
Walking programme vs placebo activity programmeFA/B12/B6 vs placebo pills
MenWomenMenWomen
WP (n = 37)PAP (n = 48)WP (n = 40)PAP (n = 27)Vitamin B (n = 44)Placebo (n = 41)Vitamin B (n = 34)Placebo (n = 33)
Age (mean (SD))74 (2.7)75 (2.8)76 (2.9)75 (2.9)75 (2.7)74 (2.9)76 (2.9)76 (2.9)
MMSE (median (25th–75th percentile)29 (28–29)29 (28–29)29 (28–29)29 (28–30)28 (28–29)29 (28–29)29 (29–30)29 (28–30)
% low/intermediate/high education†57/16/2742/35/2364/28/870/19/1161/21/18 *34/34/3252/33/15 *82/15/3
% living with partner8785505682905352
PA, min/day (median (25th–75th percentile))‡79 (63–137)79 (36–124)53 (42–80)48 (33–110)77 (55–125)81 (35–125)55 (41–89)51 (33–80)
% deficient FA/B12/B6¶35/5/042/6/055/10/059/11/039/7/039/5/062/12/052/9/0
% hyperhomocysteinemia§2733201532292115
% hypertension**19328193022187
BMI, kg/m2 (mean (SD))26.5 (3.4)26.9 (3.1)26.7 (3.0)28.3 (4.0)27 (3.4)26.5 (3.0)27.5 (3.9)27.5 (3.0)
% smokers111515151871516
  • BMI, body mass index; FA/B12/B6, folic acid, vitamins B12 and B-6 ; MMSE, mini mental state examination; PA, physical activity; PAP, placebo activity programme; WP, walking programme.

  • *Significant difference between FA/B12/B6 and placebo supplementation (p<0.05).

  • †low, no education, primary education, lower vocational training, intermediate, intermediate level secondary education, intermediate vocational training, high, higher level secondary education, higher vocational training, university training; ‡⩾3.0 metabolic equivalents; ¶cut-off points: FA red blood cell <305 nmol/l or FA plasma <6.3 nmol/l, B12 ⩽150 pmol/l, B-6 <20 nmol/l; §homocysteine >14 mmol/l; **hypertension, diastole ⩾90 mm Hg and systole ⩾160 mm Hg.