| 1. Treatment allocation |
| a. Was a method of randomisation performed? Yes/No/Don’t know |
| b. Was the treatment allocation concealed? Yes/No/Don’t know |
| 2. Were the groups similar at baseline regarding the most important prognostic indicators? Yes/No/Don’t know |
| 3. Were the eligibility criteria specified? Yes/No/Don’t know |
| 4. Was the outcome assessor blinded? Yes/No/Don’t know |
| 5. Was the care provider blinded? Yes/No/Don’t know |
| 6. Was the patient blinded? Yes/No/Don’t know |
| 7. Were point estimates and measures of variability presented for the primary outcome measures? Yes/No/Don’t know |
| 8. Did the analysis include an intention-to-treat analysis? Yes/No/Don’t know |