Table 3 Genotype and allele frequency distributions of the SNP analysed within the 3′-UTR of the COL5A1 gene in the control and Achilles tendinopathy groups of the Australian and South African subjects

SNP	Genotype frequency			CON	CON	Genotype frequency			TEN	TEN	Minor allele	Minor allele frequency		Genotype	Allele
SNP	CON WW	CON WS	CON SS	N	HWE	TEN WW	TEN WS	TEN SS	N	HWE	Minor allele	CON	TEN	p Value	p Value
Australian cohort
rs10858286	0.36	0.48	0.16	210	0.887	0.40	0.40	0.20	85	0.120	C	0.40	0.40	0.468	0.926
rs13946*	0.55	0.37	0.08	210	0.477**	0.62	0.35	0.03	85	0.505**	C	0.26	0.20	0.197	0.155
rs12722†	0.35	0.40	0.24	210	0.012††	0.20	0.68	0.12	85	0.001††	C	0.45	0.46	<0.001	0.917
rs3196378‡	0.17	0.56	0.26	206	0.063	0.09	0.75	0.16	79	<0.001	A	0.46	0.46	0.016	0.977
rs11103544§	0.74	0.24	0.03	189	0.558	0.69	0.30	0.01	80	0.680	C	0.15	0.16	0.470¶¶	0.601
rs4504708	0.57	0.35	0.07	209	0.460	0.59	0.39	0.02	83	0.336	G	0.25	0.22	0.285	0.479
rs3128575	0.10	0.38	0.52	210	0.240	0.04	0.38	0.58	85	0.541	T	0.29	0.23	0.178	0.177
South African cohort
rs13946*¶	0.58	0.31	0.11	132	0.040‡‡	0.58	0.38	0.04	93	0.772‡‡	C	0.26	0.23	0.182	0.507
rs12722†	0.30	0.42	0.28	131	0.080§§	0.37	0.51	0.13	93	0.660§§	C	0.49	0.38	0.024	0.021
rs3196378‡	0.25	0.50	0.25	125	1.000	0.20	0.59	0.21	90	0.139	A	0.50	0.49	0.464	0.922
rs11103544§	0.68	0.28	0.04	126	0.544	0.62	0.32	0.06	90	0.550	C	0.18	0.22	0.629	0.327

Genotype and allele frequencies are expressed as percentages. HWE is the p value for exact tests for Hardy–Weinberg equilibrium. Single nucleotide polymorphisms (SNP) rs10858286, rs13946, rs12722, rs11103544 and rs3128575 are a C or T. SNP rs3196378 is a C or A, whereas rs4504708 is a T or G. W is a T or A and S is a C or G. *DpnII, †BstUI, ‡AciI and §MboII restriction fragment length polymorphisms. ¶Previously published in Mokone et al.9 HWE p values for the combined control (CON) and tendinopathy (TEN) subjects. **0.154, ††0.279, ‡‡0.277 and §§0.391. ¶¶p Value TT genotype versus combined CT and CC genotypes. UTR, untranslated region.