Relative risk of all-cause mortality across each exposure and confounder categories
| Men | Women | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No | Deaths (n) | Person-years | Rate* | RR† (95% CI) | No | Deaths (n) | Person-years | Rate* | RR† (95% CI) | |
| Physical activity‡ | ||||||||||
| Inactive | 12 572 | 779 | 203 666 | 37.0 | 1.00 (referent) | 3968 | 129 | 60 155 | 19.3 | 1.00 (referent) |
| Insufficient | 5518 | 279 | 83 598 | 30.9 | 0.84 (0.73 to 0.96) | 1970 | 46 | 26 457 | 16.4 | 0.85 (0.61 to 1.20) |
| Recommended | 13 728 | 434 | 178 189 | 27.0 | 0.73 (0.65 to 0.82) | 4617 | 55 | 48 201 | 14.6 | 0.76 (0.55 to 1.05) |
| p Trend | <0.001 | 0.22 | ||||||||
| Cardiorespiratory fitness§ | ||||||||||
| Low | 4277 | 354 | 65 438 | 58.1 | 1.00 (referent) | 1115 | 57 | 16 903 | 29.1 | 1.00 (referent) |
| Moderate | 12 697 | 610 | 187 408 | 31.9 | 0.55 (0.48 to 0.63) | 3640 | 89 | 50 996 | 16.3 | 0.56 (0.40 to 0.78) |
| High | 14 844 | 528 | 212 715 | 24.2 | 0.42 (0.36 to 0.48) | 5800 | 84 | 66 932 | 14.6 | 0.50 (0.36 to 0.71) |
| p Trend | <0.001 | <0.001 | ||||||||
| Body mass index, kg/m2 | ||||||||||
| <25.0 | 12 017 | 557 | 195 997 | 27.3 | 1.00 (referent) | 8041 | 173 | 108 714 | 16.3 | 1.00 (referent) |
| 25.0–29.9 | 15 014 | 683 | 211 998 | 31.2 | 1.14 (1.02 to 1.28) | 1791 | 42 | 19 003 | 19.2 | 1.18 (0.84 to 1.66) |
| ≥30.0 | 4787 | 252 | 57 492 | 51.1 | 1.87 (1.61 to 2.18) | 723 | 15 | 7100 | 23.5 | 1.45 (0.85 to 2.46) |
| p Trend | <0.001 | 0.29 | ||||||||
| Smoking status | ||||||||||
| Never | 22 622 | 1005 | 341 140 | 28.0 | 1.00 (referent) | 8318 | 176 | 107 219 | 15.1 | 1.00 (referent) |
| Former | 3643 | 75 | 39 417 | 29.4 | 1.05 (0.81 to 1.37) | 1217 | 13 | 12 535 | 17.7 | 1.17 (0.64 to 2.17) |
| Current | 5553 | 412 | 84 850 | 49.7 | 1.77 (1.58 to 1.99) | 1020 | 41 | 15 086 | 30.6 | 2.03 (1.44 to 2.86) |
| p Trend | <0.001 | <0.001 | ||||||||
| Hypertension | ||||||||||
| No | 22 607 | 876 | 342 044 | 27.4 | 1.00 (referent) | 8932 | 176 | 116 027 | 16.7 | 1.00 (referent) |
| Yes | 9211 | 616 | 123 520 | 45.0 | 1.65 (1.48 to 1.83) | 1623 | 54 | 18 778 | 19.6 | 1.17 (0.86 to 1.61) |
| Diabetes | ||||||||||
| No | 30 527 | 1383 | 452 105 | 31.1 | 1.00 (referent) | 10 186 | 221 | 131 807 | 16.9 | 1.00 (referent) |
| Yes | 1291 | 109 | 13 336 | 65.8 | 2.12 (1.74 to 2.58) | 369 | 9 | 2993 | 25.6 | 1.52 (0.78 to 2.95) |
| Hypercholesterolemia | ||||||||||
| No | 23 077 | 1022 | 347 540 | 30.7 | 1.00 (referent) | 8416 | 176 | 110 923 | 17.5 | 1.00 (referent) |
| Yes | 8741 | 470 | 117 916 | 36.0 | 1.17 (1.05 to 1.31) | 2139 | 54 | 23 871 | 14.9 | 0.85 (0.62 to 1.17) |
| Parental cardiovascular disease | ||||||||||
| No | 23 391 | 888 | 335 427 | 30.9 | 1.00 (referent) | 7860 | 131 | 98 879 | 16.8 | 1.00 (referent) |
| Yes | 8427 | 604 | 130 029 | 35.1 | 1.14 (1.02 to 1.26) | 2695 | 99 | 35 924 | 17.8 | 1.06 (0.81 to 1.39) |
↵* Death rate per 10 000 person-years adjusted for age and examination year.
↵† Adjusted for age and examination year.
↵‡ Inactive, insufficient and recommended was defined as 0, 1.499, and .500 MET-minutes/week, respectively.
↵§ Low, moderate and high was defined as the least fit 20%, the next fit 40% and the most fit 40%, respectively.
MET, metabolic equivalent.