Table 2

Genotype frequency distributions and minor allele frequencies of IL-1β −31T→C (rs1143627), −511C→T (rs16944) and IL-6 −172G→C (rs1800795) SNPs and the VNTR in control (CON) and Achilles tendinopathy (TEN) groups of South Africa (SA) and Australia (AUS)

	CON		TEN		p Values
	SA	AUS	SA	AUS	Country	Diagnosis	Gender
IL-1β −31T→C
n	140	188	82	73
TT	0.33	0.40	0.45	0.44	0.341	0.380	0.146
TC	0.48	0.39	0.37	0.39
CC	0.19	0.21	0.18	0.18
C allele	0.43	0.41	0.37	0.37	0.461	0.245	0.053
HWE	0.863	0.010	0.056	0.135
IL-1β −511C→T
n	158	191	89	81
CC	0.32	0.31	0.38	0.33	0.545	0.097	0.651
CT	0.47	0.45	0.49	0.49
TT	0.21	0.25	0.12	0.17
T	0.45	0.47	0.37	0.42	0.375	0.065	0.365
HWE	0.631	0.147	0.654	1
IL-6 −172G→C
n	147	190	80	77
GG	0.42	0.25	0.39	0.40	0.023	0.183	0.347
GC	0.40	0.51	0.51	0.40
CC	0.18	0.24	0.10	0.20
C	0.38	0.49	0.36	0.40	0.006	0.078	0.841
HWE	0.080	0.772	0.341	0.160
IL-1RN VNTR
n	153	198	83	82
A4/A4	0.51	0.46	0.49	0.51	0.070	0.779	0.243
A4/A2	0.41	0.39	0.42	0.32
A4/A5	0.03	0.02	0.04	0.05
A4/A1	0.00	0.02	0.01	0.00
A2/A2	0.06	0.10	0.04	0.12
A2/A5	0.00	0.01	0.00	0.00
A4	0.73	0.68	0.73	0.70	0.126	0.643	0.831
A2	0.26	0.30	0.25	0.28	0.220	0.562	0.846
A5	0.01	0.01	0.02	0.02	0.667	0.465	0.194
A1	0.00	0.01	0.01	0.00	0.220	0.544	0.654
HWE	1	0.965	1	1

p Values are for comparing distributions between countries, adjusting for gender and diagnosis; between diagnoses, adjusting for gender and population and between genders, adjusting for diagnosis and population group. HWE are p values from tests of Hardy–Weinberg equilibrium, exact for the SNPs and χ² for the VNTR. n is number typed.
SNPs, single-nucleotide polymorphisms; VNTR, variable nucleotide tandem repeat.