Pharmacotherapy for persistent post-traumatic headache
| Paper | Study type/setting | Subject characteristics | Treatment | Findings/results |
|---|---|---|---|---|
| Weiss et al66 | Case series | 14 Mild TBI and 7 whiplash injury patients diagnosed with migraines postinjury | Propranolol and/or amitriptyline | ‘Dramatic reduction’ in the frequency and severity of headaches in 70% |
| McBeath and Nanda67 | Case series | 34 Patients referred to headache clinic with headache as part of a postconcussion syndrome | Repeat intravenous dihydroergotamine and metoclopramide | Reported a good-to-excellent response in 29 of 34 patients. Also noted improvement in memory symptoms, sleep disturbance and dizziness |
| Packard68 | Retrospective cohort | 100 Patients with chronic daily headache of between 2 and 6 months duration following mild TBI | Valproate | 60% Reported mild-to-moderate improvement after 1 month of treatment. The remaining 40% either showed no response (26%) or stopped treatment because of side effects |
TBI, traumatic brain injury.