Table 3

Neuronal quantitative results in format p50 (p25–p75), % area stained unless otherwise stated (pc denotes percentage area stained has been adjusted per cell)

 Group
 RCR 0 weeksRCR 7 weeks GCI 0 weeksGCI 7 weeks
 p50 (p25–p75)p50 (p25–p75)p50 (p25–p75)p50 (p25–p75)
Glutaminergic system
Glutamate0.35 (0.23–1.1)*3.4 (2.1–7.1)*0.31 (0.22–1.7)*1.6 (0.56–2.2)*
NMDAR1pc0.23 (0.1–0.42)††0.26 (0.07–0.42)0.02 (0.004–0.07)*††0.07 (0.01–0.16)*
AMPApc0.66 (0.27–1.3)0.84 (0.14–2.2)0.38 (0.20–1.1)0.45 (0.13–0.81)
mGluR1pc0.16 (0.06–0.57)*0.83 (0.13–1.47)*0.12 (0.05–0.36)*0.39 (0.15–0.55)*
mGluR2pc0.22 (0.18–0.48)0.32 (0.07–0.37)0.20 (0.12–0.38)0.22 (0.08–0.34)
mGluR3pc0.09 (0.04–0.11)††0.13 (0.01–0.38)0.02 (0.01–0.03)††0.05 (0.02–0.09)
mGluR4pc0.19 (0.12–0.40)††0.32 (0.08–0.52)0.03 (0.01–0.11)††0.09 (0.03–0.12)
mGluR5pc0.04 (0.01–0.06)0.03 (0.02–0.06)0.01 (0.01–0.04)0.02 (0.02–0.05)
mGluR7pc0.01 (0.002–0.02)*0.04 (0.02–0.10)*0.002 (0.001–0.006)0.02 (0.007–0.03)
mGluR8pc0.02 (0.01–0.06)0.02 (0.004–0.05)0.01 (0.007–0.02)0.01 (0.004–0.05)
Sensory nervous system and neurotrophins
Substance P3.6 (0.66–5.5)4.0 (2.5–6.3)2.4 (0.23–4.2)2.6 (1.4–3.6)
NK-10.84 (0.48–2.7)*3.6 (1.8–6.8)*1.7 (0.94–3.2)2.2 (1.6–3.2)
P756.4 (5.5–10.4)*15.3 (11.8–20.9)*4.6 (0.06–11.8)5.5 (0.37–14.8)
NGF0.22 (0.15–0.88)0.9 (0.57–1.8)0.21 (0.05–0.41)0.29 (0.10–0.60)
TrkA0.91 (0.28–1.9)*†6.4 (2.7–9.0)*4.7 (2.7–5.5)†2.9 (2.5–4.7)
Neural markers
PGP9.5 pc0.10 (0.03–0.17))**0.52 (0.30–0.67))**0.06 (0.04–0.15)0.09 (0.07–0.14)
GAP43 pc0.06 (0.02–0.15)0.14 (0.05–0.20)0.04 (0.01–0.13)0.02 (0.01–0.13)
  • *p<0.05; ** p<0.01 (between 0 and 7 week groups).

  • †p<0.05; ††p<0.01 (between RCR 0 weeks and GCI 0 weeks).

  • GCI, glucocorticoid injection; mGluR, metabotropic Glutamate Receptor; NGF, Nerve Growth Factor; NMDAR1, N-methyl-D-aspartate receptor 1; pc, per cell; PGP, Protein Gene Product; RCR, rotator cuff repair.