Group | ||||
---|---|---|---|---|
RCR 0 weeks | RCR 7 weeks | GCI 0 weeks | GCI 7 weeks | |
p50 (p25–p75) | p50 (p25–p75) | p50 (p25–p75) | p50 (p25–p75) | |
Glutaminergic system | ||||
Glutamate | 0.35 (0.23–1.1)* | 3.4 (2.1–7.1)* | 0.31 (0.22–1.7)* | 1.6 (0.56–2.2)* |
NMDAR1pc | 0.23 (0.1–0.42)†† | 0.26 (0.07–0.42) | 0.02 (0.004–0.07)*†† | 0.07 (0.01–0.16)* |
AMPApc | 0.66 (0.27–1.3) | 0.84 (0.14–2.2) | 0.38 (0.20–1.1) | 0.45 (0.13–0.81) |
mGluR1pc | 0.16 (0.06–0.57)* | 0.83 (0.13–1.47)* | 0.12 (0.05–0.36)* | 0.39 (0.15–0.55)* |
mGluR2pc | 0.22 (0.18–0.48) | 0.32 (0.07–0.37) | 0.20 (0.12–0.38) | 0.22 (0.08–0.34) |
mGluR3pc | 0.09 (0.04–0.11)†† | 0.13 (0.01–0.38) | 0.02 (0.01–0.03)†† | 0.05 (0.02–0.09) |
mGluR4pc | 0.19 (0.12–0.40)†† | 0.32 (0.08–0.52) | 0.03 (0.01–0.11)†† | 0.09 (0.03–0.12) |
mGluR5pc | 0.04 (0.01–0.06) | 0.03 (0.02–0.06) | 0.01 (0.01–0.04) | 0.02 (0.02–0.05) |
mGluR7pc | 0.01 (0.002–0.02)* | 0.04 (0.02–0.10)* | 0.002 (0.001–0.006) | 0.02 (0.007–0.03) |
mGluR8pc | 0.02 (0.01–0.06) | 0.02 (0.004–0.05) | 0.01 (0.007–0.02) | 0.01 (0.004–0.05) |
Sensory nervous system and neurotrophins | ||||
Substance P | 3.6 (0.66–5.5) | 4.0 (2.5–6.3) | 2.4 (0.23–4.2) | 2.6 (1.4–3.6) |
NK-1 | 0.84 (0.48–2.7)* | 3.6 (1.8–6.8)* | 1.7 (0.94–3.2) | 2.2 (1.6–3.2) |
P75 | 6.4 (5.5–10.4)* | 15.3 (11.8–20.9)* | 4.6 (0.06–11.8) | 5.5 (0.37–14.8) |
NGF | 0.22 (0.15–0.88) | 0.9 (0.57–1.8) | 0.21 (0.05–0.41) | 0.29 (0.10–0.60) |
TrkA | 0.91 (0.28–1.9)*† | 6.4 (2.7–9.0)* | 4.7 (2.7–5.5)† | 2.9 (2.5–4.7) |
Neural markers | ||||
PGP9.5 pc | 0.10 (0.03–0.17))** | 0.52 (0.30–0.67))** | 0.06 (0.04–0.15) | 0.09 (0.07–0.14) |
GAP43 pc | 0.06 (0.02–0.15) | 0.14 (0.05–0.20) | 0.04 (0.01–0.13) | 0.02 (0.01–0.13) |
*p<0.05; ** p<0.01 (between 0 and 7 week groups).
†p<0.05; ††p<0.01 (between RCR 0 weeks and GCI 0 weeks).
GCI, glucocorticoid injection; mGluR, metabotropic Glutamate Receptor; NGF, Nerve Growth Factor; NMDAR1, N-methyl-D-aspartate receptor 1; pc, per cell; PGP, Protein Gene Product; RCR, rotator cuff repair.