Table 1

Details of the used PRP compilation and Mishra classification of PRP

ReferencesInjections (N)/interval (weeks)/volume (mL)Spinning approachWhite cells countActivationPlatelet concentrationType PRP (Mishra classification)
Vaquerizo et al36*3/2/8Single spinning+<5×baseline4B
Patel et al37*1(2)/–(3)/8Single spinning+<5×baseline4B
Filardo et al38 44*3/1/5Double spinning++5×baseline2A
Cerza et al39*4/1/5.5Single spinning>5×baseline3A
Sánchez et al40*3/1/8Single spinning+<5×baseline4B
Say et al411/–/2.5Single spinning+<5×baseline4B
Spaková et al423/1/33 spinnings+<5×baseline1B
Li et al433/3/3.5NANA+NANA
Filardo et al233(3)/3(3)/5(5)Single vs double spinning− (+)+(+)<5×baseline4B (2B)
Kon et al16 453/2/5Double spinning++>5×baseline2A
  • Type 1 PRP: increased white cells count and no activation; type 2 PRP: increased white cells count and activated; type 3 PRP: minimal/no white cells count and no activation; type 4 PRP: minimal/no white cells count and activated.

  • A: contains an increased platelet concentration at or above five times baseline (extracted venous blood).

  • B: contains an increased platelet concentration less than five times baseline (extracted venous blood).

  • *Included randomised controlled trials.

  • Values in brackets in the Patel's study: group B (2 platelet-rich injections).

  • Values in brackets in the Filardo's study: comparison group (double-spinning approach).

  • NA, not applicable; PRP, platelet-rich plasma.