Influence of determinants on tibiofemoral radiological OA outcome in operatively and operatively/non-operatively treated cohorts
| Group | Determinant | Number of studies | Significant relationship LR/HR: n studies | No significant relationship LR/HR: n studies | Best-evidence synthesis | Comments |
|---|---|---|---|---|---|---|
| Patient characteristics | Older age | 6 | Positive relationship: HR: 243 66 | LR: 156 HR: 337 40 60 | Conflicting evidence | |
| Higher BMI | 4 | Positive relationship: LR: 156* HR: 166 | HR: 240 43 | Conflicting evidence | *Ahn et al:56 lateral OA | |
| Male sex | 3 | Positive relationship: HR: 143 | HR: 260 66 | Conflicting evidence | ||
| Intra-articular- related factors | Additional injury | 2 | Positive relationship: HR: 144 | HR: 163 | Conflicting evidence | |
| Chondral injury | 3 | Positive relationship: HR: 237 60 | HR: 166 | Conflicting evidence | ||
| Meniscal injury/meniscectomy | 11 | Positive relationship: Medial meniscus injury/meniscectomy: LR: 156 HR: 220 57 Lateral meniscus injury/meniscectomy: HR: 157 Location not reported: HR: 637 40 60 69 80 81 | Medial meniscus injury/meniscectomy: None Lateral meniscus injury/meniscectomy: LR: 156 HR: 120 Location not reported: HR: 248 66 | Medial meniscus injury/meniscectomy: Moderate evidence positive relationship Lateral meniscus injury/meniscectomy: Conflicting evidence Location not reported: Limited evidence positive relationship | ||
| Longer time between injury and reconstruction | 6 | Positive relationship HR: 161 | LR: 156 HR: 437 43 60 66 | Moderate evidence for no relationship | ||
| ACL reconstruction (vs non-operative treatment) | 7 | Positive relationship HR: 231 40 Negative relationship: HR: 147 | HR: 419 53 70 80 | Conflicting evidence | ||
| Graft type BPTB (vs HT) | 8 | Positive relationship HR: 4*37 38 43 52 | HR: 6**18 19 21 38 52 69 | Conflicting evidence | *Leys et al:38 medial OA; Mascarenhas et al:52 lateral OA **Leys et al:38 lateral OA; Mascarenhas et al:52 medial OA |
*Refers to the comment in the last column in the same row.
ACL, anterior cruciate ligament; BMI, body mass index; BPTB, bone-patellar tendon-bone; HR, high risk of bias studies; HT, hamstring tendon; LR, low risk of bias studies; OA, osteoarthritis.