TableĀ 2

Influence of determinants on tibiofemoral radiological OA outcome in operatively and operatively/non-operatively treated cohorts

GroupDeterminantNumber of studiesSignificant relationship
LR/HR: n studies
No significant relationship
LR/HR: n studies
Best-evidence synthesisComments
Patient characteristicsOlder age6Positive relationship:
HR: 243 66
LR: 156
HR: 337 40 60
Conflicting evidence
Higher BMI4Positive relationship:
LR: 156*
HR: 166

HR: 240 43Conflicting evidence*Ahn et al:56 lateral OA
Male sex3Positive relationship:
HR: 143
HR: 260 66Conflicting evidence
Intra-articular- related factorsAdditional injury2Positive relationship:
HR: 144
HR: 163Conflicting evidence
Chondral injury3Positive relationship:
HR: 237 60
HR: 166Conflicting evidence
Meniscal injury/meniscectomy11Positive relationship:
Medial meniscus injury/meniscectomy:
LR: 156
HR: 220 57
Lateral meniscus injury/meniscectomy:
HR: 157
Location not reported:
HR: 637 40 60 69 80 81

Medial meniscus injury/meniscectomy:
Lateral meniscus injury/meniscectomy:
LR: 156
HR: 120
Location not reported:
HR: 248 66

Medial meniscus injury/meniscectomy:
Moderate evidence positive relationship
Lateral meniscus injury/meniscectomy:
Conflicting evidence
Location not reported:
Limited evidence positive relationship
Longer time between injury and reconstruction6Positive relationship
HR: 161
LR: 156
HR: 437 43 60 66
Moderate evidence for no relationship
ACL reconstruction (vs non-operative treatment)7Positive relationship
HR: 231 40
Negative relationship:
HR: 147
HR: 419 53 70 80Conflicting evidence
Graft type BPTB (vs HT)8Positive relationship
HR: 4*37 38 43 52
HR: 6**18 19 21 38 52 69Conflicting evidence*Leys et al:38 medial OA;
Mascarenhas et al:52 lateral OA
**Leys et al:38 lateral OA; Mascarenhas et al:52 medial OA
  • *Refers to the comment in the last column in the same row.

  • ACL, anterior cruciate ligament; BMI, body mass index; BPTB, bone-patellar tendon-bone; HR, high risk of bias studies; HT, hamstring tendon; LR, low risk of bias studies; OA, osteoarthritis.