Influence of determinants on radiological OA outcome compartment unspecified in operatively and operatively/non-operatively treated cohorts
| Group | Determinant | Number of studies | Significant relationship LR/HR: n studies | No significant relationship LR/HR: n studies | Best-evidence synthesis | Comments |
|---|---|---|---|---|---|---|
| Patient characteristics | Older age | 9 | Positive relationship: HR: 350 65 78 | LR: 135 HR: 525 67 68 75 79 | Conflicting evidence | |
| Higher BMI | 5 | Positive relationship: HR: 265 68 | LR: 135 HR: 267 79 | Conflicting evidence | ||
| Male sex | 6 | Positive relationship: HR: 168 | LR: 135 HR: 425 67 75 79 | Moderate evidence for no relationship | ||
| Physical examination | Laxity | 3 | LR: 135 HR: 234 45 | Moderate evidence for no relationship | ||
| Range of motion loss | 4 | Positive relationship: HR: 150 | LR: 135 HR: 234 45 | Moderate evidence for no relationship | ||
| Performance single-legged hop test | 3 | Negative relationship: HR: 145 | LR: 135 HR: 134 | Conflicting evidence | ||
| Activity | Activity level before reconstruction | 2 | LR: 135 HR: 168 | Limited evidence for no relationship | ||
| Intra-articular | Chondral injury | 8 | Medial chondral injury: Positive relationship: HR: 168 Lateral chondral injury: None Patellar chondral injury: Positive relationship: HR: 168 Location not reported Positive relationship: LR: 135 HR: 333 50 73 | Medial chondral injury: None Lateral chondral injury: HR: 168 Patellar chondral injury: None Location not reported HR: 323 25 49 | Medial chondral injury: Limited evidence for positive relationship Lateral chondral injury: Limited evidence for no relationship Patellar chondral injury: Limited evidence for positive relationship Location not reported Conflicting evidence | |
| Meniscal injury/meniscectomy | 19 | Positive relationship: Medial meniscus injury/meniscectomy: LR: 135 HR: 5 (49, 55, 67, 68: concurrent*, 75) Lateral meniscus injury/meniscectomy: None Both meniscectomy: 149 Location not reported: HR: 936 39 50 51 54 70 73 74 78 | Medial meniscus injury/meniscectomy: HR: 1 (68: prior*) Lateral meniscus injury/meniscectomy: LR: 135 HR: 4 (49, 67, 68: prior and concurrent, 75) Both meniscectomy None Location not reported: HR: 423 32 59 79 | Medial meniscus injury/meniscectomy: Moderate evidence positive relationship Lateral meniscus injury/meniscectomy: Moderate evidence no relationship Both meniscectomy: Limited evidence for positive relationship Location not reported: Conflicting evidence | *Li et al;68 concurrent: meniscectomy concurrent with ACL reconstruction; prior: meniscectomy prior to ACL reconstruction | |
| Longer time between injury and reconstruction | 7 | Positive relationship HR: 436 68 74 78 | LR: 135 HR: 225 79 | Conflicting evidence | ||
| ACL reconstruction (vs non-operative treatment) | 5 | Positive relationship: HR: 165 Negative relationship: HR: 272 77 | HR: 230 79 | Conflicting evidence | ||
| Graft type BPTB (vs HT) | 7 | Positive relationship: HR: 524 29 38 45 68 | HR: 223 28 | Conflicting evidence | ||
| Graft type allograft (vs autograft) | 2 | Positive relationship: HR: 168 | HR: 126 | Conflicting evidence | ||
| Tunnel placement | 4 | Positive relationship: HR: 168 | HR: 338 46 58 | Limited evidence for no relationship | ||
| Single bundle (vs double bundle) | 2 | HR: 225 27 | Limited evidence for no relationship |
*Refers to the comment in the last column in the same row.
ACL, anterior cruciate ligament; BMI, body mass index; BPTB, bone-patellar tendon-bone; HT, hamstring tendon; HR, high risk of bias studies; LR, low risk of bias studies; OA, osteoarthritis.