Heritability levels, number of loci with genome-wide significance and percentage of trait variance explained by these loci
| Phenotype | Heritability (%) | Number of participants | Number of loci at p<5×10−8 | Per cent of variance explained | Reference |
|---|---|---|---|---|---|
| BMI | 25–60 | 339 224 | 97 | 2.7 | 13 |
| WHR adjusted BMI | 40–55 | 224 459 | 49 | 1.4 | 15 |
| T2 diabetes | 45–90 | 149 821 | 65 | 5.7 | 18 |
| Total cholesterol | 50–60 | 188 577 | 40 | 12–14 | 19 |
| Triglycerides | 25–60 | 188 577 | 32 | 10–13 | 19 |
| hs-CRP | 25–55 | 81 870 | 18 | 20 | |
| Systolic BP | 20–70 | 203 056 | 25 | <1.0 | 21 |
| Hypertension | 50 | 203 056 | 11 | <1.0 | 21 |
The numbers are from the latest and largest meta-analysis of GWAS report for each trait.
Adapted and expanded from Rankinen et al.17
BMI, body mass index; BP, blood pressure; GWAS, genome-wide association studies; hs-CRP, high-sensitivity C reactive protein; WHR, waist to hip ratio.