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The effect of different exercise intensities on the fibrinolytic system

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Summary

The effects of moderate 30-min cycle ergometer exercise (aerobic metabolism) followed by short-term exercise at maximal capacity (anaerobic metabolism) on fibrinolytic activity were investigated in ten female and ten male healthy, untrained subjects. The following parameters of fibrinolytic activity were measured initially (t 0), at the end of the aerobic phase (t 1), at the end of the anaerobic phase (t 2) and after a 30-min recovery period (t3): tissue plasminogen activator (PAt) activity, PAt concentration, plasminogen activator inhibitor (PAi) activity, and D-Dimer concentration. Moderate long-term exercise caused a slight but significant increase in PAt concentration and PAt activity (t 1; P<0.01), whereas short-term exercise at maximal capacity (t 2) produced a substantial elevation in both these parameters (P<0.01). This would suggest that PAt was not inhibited totally by PAi which would itself seem to be consumed during exercise. In addition, a slight exercise intensity-dependent increase in D-Dimer concentration was measured — circumstancial evidence not only for elevated fibrinolytic potential, but also for an actual increase in fibrin degradation (t 2: P<0.01). After t 3 both PAt activity and D-Dimer concentration were still slightly but significantly increased. The results obtained in the tests of fibrinolytic activity showed no significant difference between the men and the women. It would seem that the release of PAt is more markedly stimulated by short-term intense physical exercise than by long-term moderate exercise and actually causes increased fibrin degradation.

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References

  • Andrew M, Carter C, O'Brodovich H, Heigenhauser G (1986) Increases in factor VIII complex and fibrinolytic activity are dependent on exercise intensity. J Appl Physiol 60:1917–1922

    PubMed  Google Scholar 

  • Astrup T (1956) Fibrinolysis in the organism. Blood 11:781–806

    Google Scholar 

  • Bärtsch P, Schmidt EK, Straub PW (1982) Fibrinopeptid A after strenuous physical exercise at high altitude. J Appl Physiol 53:40–43

    Google Scholar 

  • Cash JD (1978) Control mechanisms of activator release. In: Davidson JF, Rowan RM, Samana MM, Desnoyers PC (eds) Progress in chemical fibrinolysis and thrombolysis vol 3. Raven Press, New York, pp 65–75

    Google Scholar 

  • Chan KL, Davies RA, Chambers RJ (1984) Coronary thrombosis and subsequent lysis after a marathon. J Am Coll Cardiol 4:1322–1325

    PubMed  Google Scholar 

  • Cohen RJ, Epstein SE, Cohen LS, Dennis LH (1968) Alterations of fibrinolysis and blood coagulation induced by exercise, and the role of beta-adrenergic-receptor stimulation. Lancet 11:1264–1266

    Article  Google Scholar 

  • Collen D (1980) On the regulation and control of fibrinolysis. Thromb Haemost 43:77–89

    Google Scholar 

  • Collen D, Semeraro F, Tricot JP, Vermylen J (1977) Turnover of fibrinogen, plasminogen and prothrombin during exercise in man. J Appl Physiol 42:865–873

    PubMed  Google Scholar 

  • Crowell JW, Houston B (1961) Effect of acidity on blood coagulation. Am J Physiol 201:379–382

    PubMed  Google Scholar 

  • Das PC, Allan AGE, Woodfield DG, Cash JD (1967) Fibrin degradation products in sera of normal subjects. BMJ 4:718–720

    PubMed  Google Scholar 

  • Davis GL, Abildgaard CF, Bernauer EM, Britton M (1976) Fibrinolytic and hemostatic changes during and after maximal exercise in males. J Appl Physiol 40:287–292

    Google Scholar 

  • Drygas WK, Röcker L, Boldt F, Heyduck B, Altenkirch HU (1987) Hämostase und Fibrinolysesystem bei Gesunden und Herzinfarktpatienten. Dtsch Med Wochenschr 112:995–999

    Google Scholar 

  • Dufaux B, Order U, Liesen H (1991) Effect of a short maximal physical exercise on coagulation, fibrinolysis, and complement system. Int J Sports Med 12:38–42

    Google Scholar 

  • Elveback LR, Guillier CL, Keating FR (1970) Health, normality and the ghost of gauss. J Am Med Assoc 211:69–75

    Google Scholar 

  • Ferguson EW, Barr CF, Bernier LL (1979) Fibrinogenolysis and fibrinolysis with strenuous exercise. J Appl Physiol 47:1157–1161

    Google Scholar 

  • Ferguson EW, Bernier LL, Banta GR, Yu-Yahiro J, Schoomaker EB (1987) Effects of exercise and conditioning on clotting and fibrinolytic activity in men. J Appl Physiol 62:1416–1421

    Google Scholar 

  • Gelehrter TD, Sznycer-Laszuk R (1986) Thrombin induction of plasminogen activator-inhibitor in cultured human endothelial cells. J Clin Invest 77:165–169

    PubMed  Google Scholar 

  • Hawkey CM, Britton BJ, Wood WG, Peele M, Irving MH (1975) Changes in Blood catecholamine levels and blood coagulation and fibrinolytic activity in response to graded exercise in man. Br J Haematol 29:377–384

    PubMed  Google Scholar 

  • Hays WL (1970) Statistics. Holt, Rinehart and Winston, London, pp 633–637

    Google Scholar 

  • Hyers TM, Martin BJ, Pratt DS, Dreisin RB, Franks JJ (1980) Enhanced thrombin and plasmin activity with exercise in man. J Appl Physiol 48:821–825

    Google Scholar 

  • Karp JE, Bell WR (1974) Fibrinogen-fibrin degradation products and fibrinolysis following exercise in humans. Am J Physiol 227:1212–1215

    Google Scholar 

  • Keber D, Stegnar M, Keber I, Accetto B (1979) Influence of moderate and strenuous daily physical activity on fibrinolytic activity of blood: possibility of plasminogen activator stores depletion. Thromb Haemost 41:745–755

    Google Scholar 

  • Kluft C (1977) An inventory of plasminogen activators in human plasma (Abstr.) Thromb Haemost 38:134

    Google Scholar 

  • Kluft C (1979) Studies on the fibrinolytic system in human plasma: quantitative determination of plasminogen activators and proactivators. Thromb Haemost 41:365–383

    Google Scholar 

  • Levine EG, Stern DM, Nawroth PP, Marlar RA, Fair DS, Fenton IW II, Harker LA (1986) Specificity of the thrombin-induced release of tissue plasminogen activator from cultured human endothelial cells. Thromb Haemost 56:115–119

    Google Scholar 

  • Loskutoff DJ, Edgington T (1977) Synthesis of a fibrinolytic activator and inhibitor by endothelial cells. Proc Natl Acad Sci USA 74:3903–3907

    Google Scholar 

  • Mandalaki T, Dessypris A, Louizou C, Bossinakou I, Panayotopoulou C, Atonopoulou A (1977) Marathon run I. Effects on blood coagulation and fibrinolysis. Thromb Haemost 37:444–450

    Google Scholar 

  • Marsh N, Gaffney P (1980) Some observations on the release of extrinsic and intrinsic plasminogen activators during exercise in Man. Haemostasis 9:238–247

    Google Scholar 

  • Marsh NA, Gaffney PJ (1982) Exercise-induced fibrinolysis — fact or fiction? Thromb Haemost 48:201–203

    PubMed  Google Scholar 

  • Nilsson IM, Hedner U, Pandolfi M (1978) The measurement of fibrinolytic activities. In: Markwardt F (ed) Handbook of experimental pharmacology, new series vol. 46. Springer Verlag, Berlin, Heidelberg, New York, pp 107–134

    Google Scholar 

  • Rijken DC, Wijngaards G, Welbergen J (1980) Relationship between tissue plasminogen activator and the activators in blood and vascular wall. Thromb Res 18:815–830

    Google Scholar 

  • Röcker L, Franz IW (1986) Effect of chronic β-adrenergic blockade on exercise-induced leukocytosis. Klin Wochenschr 64:270–273

    PubMed  Google Scholar 

  • Röcker L, Drygas WK, Heyduck B (1986) Blood platelet activation and increase in thrombin activity following a marathon race. Eur J Appl Physiol 55:374–380

    Google Scholar 

  • Röcker L, Taenzer M, Drygas WK, Lill H, Heyduck B, Altenkirch HU (1990) Effect of prolonged physical exercise on the fibrinolytic system. Eur J Appl Physiol 60:478–481

    Google Scholar 

  • Rosing DR, Brakman P, Redwood DR, Goldstein RE, Beiser GD, Astrup P, Epstein SE (1970) Blood fibrinolytic activity in Man. Diurnal variation and the response to varying intensities of exercise. Circ Res 27:171–183

    Google Scholar 

  • Sherry S, Fletcher AP, Alkjaersig N (1959) Fibrinolysis and fibrinolytic activity in Man. Physiol Rev 39:343–382

    Google Scholar 

  • Sprengers ED, Kluft C (1987) Plasminogen activator inhibitors. Blood 69:381–387

    Google Scholar 

  • Strauss MB, Davis RK, Rosenbaum JD, Rossmeisl EC (1951) “Water diuresis” produced during recumbency by the intravenous infusion of isotonic saline solution. J Clin Invest 30:862–868

    Google Scholar 

  • Vogt A, Hofmann V, Straub PW (1979) Lack of fibrin formation in exercise-induced activation of coagulation. Am J Physiol 236: H577-H579

    PubMed  Google Scholar 

  • Wiman B, Melbring G, Ranby M (1983) Plasminogen activtor release during venous stasis and exercise as determined by a new specific assay. Clin Chim Acta 127:279–288

    Google Scholar 

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Molz, AB., Heyduck, B., Lill, H. et al. The effect of different exercise intensities on the fibrinolytic system. Eur J Appl Physiol 67, 298–304 (1993). https://doi.org/10.1007/BF00357626

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