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Heat shock proteins and drug resistance

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Summary

Heat shock proteins (hsp's) are induced in cells when exposed to different environmental stressful conditions. We have found that breast cancer cells sometimes express high levels of several hsp's, which may both augment the aggressiveness of these tumors and make them more resistant to treatment. We have shown that hsp70 is an ominous prognostic sign as detected by Western blot assays in node-negative breast tumors, and that hsp27 increases specific resistance to doxorubicin in breast cancer cell lines. These findings have direct clinical application, and suggest that modulating hsp expression may be a therapeutic target for reversal of hsp-associated detrimental cellular effects.

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Authors and Affiliations

  1. Department of Medicine, Division of Medical Oncology, University of Texas Health Science Center, 7703 Floyd Curl Drive, 78284-7884, San Antonio, Texas, USA

    Suzanne A. W. Fuqua, Steffi Oesterreich, Susan G. Hilsenbeck & C. Kent Osborne

  2. Cancer Therapy and Research Center, 78224, San Antonio, Texas, USA

    Daniel D. Von Hoff & John Eckardt

Authors
  1. Suzanne A. W. Fuqua
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  2. Steffi Oesterreich
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  3. Susan G. Hilsenbeck
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  4. Daniel D. Von Hoff
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  5. John Eckardt
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  6. C. Kent Osborne
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Fuqua, S.A.W., Oesterreich, S., Hilsenbeck, S.G. et al. Heat shock proteins and drug resistance. Breast Cancer Res Tr 32, 67–71 (1994). https://doi.org/10.1007/BF00666207

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