Skip to main content
Log in

Beeinflussung von Blutgerinnung und Fibrinolyse durch körperliche Aktivität

Influence of physical training on blood coagulation and fibrinolysis

  • Übersichten
  • Published:
Klinische Wochenschrift Aims and scope Submit manuscript

Summary

Physical conditioning appears to protect against the development of vascular disease. Although physical training often evokes favorable alterations in established cardiovascular risk factors, such as plasma lipids and lipoproteins, the metabolic sequelae of regular exercise that mediate a reduction in the risk of cardiovascular disease remain incompletely understood. Studies in recent years have shown physical training to have beneficial effects on blood coagulation and fibrinolytic activity. On general the data support the concept that blood clotting is potentiated by exercise. Mechanisms involved are an increased release of thromboplastine of tissue, increased coagulation with lactate accumulation during exercise, increased concentrations of plasma proteins owing to hemoconcentration, increased concentrations of specific clotting factors, e.g., Factor VIII and fibrinogen, and an alteration in platelet count and platelet function. The acceleration in coagulation is less in the well-exercised individual. There is evidence that an epinephrine mediated mechanism is responsible for the difference between individuals who have a lot of exercise and those who do not. Fibrinolytic activity seems to increase with exercise in a linear relationship with the heart rate during physical activity. An enhancement of the plasma fibrinolytic activity, stimulated experimentally by thrombotic stress such as venous occlusion, could be an important mechanism in the beneficial effect of habitual physical exercise on the risk of cardiovascular disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Astrand PO, Saltin B (1964) Plasma and red cell volume after prolonged severe exercise. J Appl Physiol 19:829

    Google Scholar 

  2. Astrup T (1978) Fibrinolysis: An Overview. Prog Chem Fibrinol Thromb 3:1

    Google Scholar 

  3. Bennett NB, Ogston CM, Ogston D (1968) The effect of prolonged exercise on the components of the blood fibrinolytic enzyme system. J Physiol 198:479

    Google Scholar 

  4. Binder BR, Spragg J, Austen KF (1979) Purification and characterization of human vascular plasminogen activator derived from blood vessels perforates. J Biol Chem 254:1198

    Google Scholar 

  5. Böhmer D (1974) Sport und Blutgerinnung. Med Klin 69:239

    Google Scholar 

  6. Breddin K, Hach W (1966) Agglutination und Adhäsivität der Thrombozyten nach körperlicher Belastung. Thromb Diath haemorrh 15:109

    Google Scholar 

  7. Broustet JP, Boisseau M, Boulloumie J, Emmeriau JP, Series E, Bricaud H (1978) The effects of acute exercise and physical training on platelet function in patients with coronary artery disease. Cardiac Rehabilitation 9:28

    Google Scholar 

  8. Cash JD, Allan AGE (1967) The fibrinolytic response to moderate exercise and intravenous adrenaline in the same subjects. Br J Haematol 13:376

    Google Scholar 

  9. Cohen RJ, Cohen LS, Epstein SE, Dennis LH (1968) Alterations of fibrinolysis and blood coagulation induced by exercise, and the role of beta-adrenergic-receptor stimulation. Lancet II:1264

    Google Scholar 

  10. Crowell JW, Houston B (1961) Effect of acidity on blood coagulation. Am J Physiol 201:379

    Google Scholar 

  11. Davis GL, Abidgaard CF, Bernauer EM, Britton M (1976) Fibrinolytic and hemostatic changes during and after maximal exercise in males. J Appl Physiol 40:287

    Google Scholar 

  12. Dawson AA, Ogston D (1969) Exercise-induced thrombocytosis. Acta Haematol 42:241

    Google Scholar 

  13. Diehm C, Mörl H, Wirth A, Schettler G (1981) Körperliches Training als Prophylaxe arteriosklerotischer Gefäßerkrankungen. Therapiewoche 31:5363

    Google Scholar 

  14. Diehm C, Mörl H, Matthes D, Hoffmann G, Zimmermann B, Wirth A, Harenberg J (1982) Körperliche Aktivität, Blutgerinnung und Fibrinolyse. In: Kommerell B, Hahn P, Kübler W, Mörl H, Weber E (Hrsg) Fortschritte in der Inneren Medizin. Springer, Berlin Heidelberg New York, pp 139–145

    Google Scholar 

  15. Egeberg O (1963) The effect of exercise on the blood clotting system. Scand J Clin Lab Invest 15:8

    Google Scholar 

  16. Epstein SE, Rosing DR, Brakman P, Redwood DR, Astrup T (1970) Impaired fibrinolytic response to exercise in patients with type IV hyperlipoproteinaemia. Lancet II:631

    Google Scholar 

  17. Ferguson EW, Guest MU (1975) Exercise, physical conditioning, blood coagulation, and fibrinolysis. Thromb Diath Haematol 29:377

    Google Scholar 

  18. Finkel A, Cumming GR (1965) Effects of exercise in the cold in blood clotting and platelets. J Appl Physiol 20:423

    Google Scholar 

  19. Fowler WM, Showdbury SR, Pearson CH, Gardner G et al. (1962) Changes in serum enzyme levels after exercise in trained and untrained subjects. J Appl Physiol 17:943

    Google Scholar 

  20. Hartley L, Mason J, Hogan R, Jones L et al. (1972) Multiple hormonal responses to graded exercise in relation to physical training. J Appl Physiol 33:602

    Google Scholar 

  21. Hawkey CM, Britton BJ, Wood WG, Peele M, Irving M (1975) Changes in blood catecholamin levels and blood coagulation and fibrinolytic activity in response to graded exercise in man. Br J Haematol 29:377

    Google Scholar 

  22. Iatridas SG, Ferguson JH (1963) Effect of physical exercise on blood clotting and fibrinolysis. J Appl Physiol 18:337

    Google Scholar 

  23. Ikkala E, Myllylä G, Sarajas HSS (1963) Haemostatic changes associated with exercise. Nature 199:459

    Google Scholar 

  24. Kessler KA, Egli H, Wachholder K (1957) Über die Einwirkung körperlicher Arbeit auf die Blutgerinnung. Klin Wochenschr 35:1088

    Google Scholar 

  25. Keul J, Berg A, Lehmann M, Dickhuth HH (1980) Metabolische Anpassung durch Training und ihr Aussagewert für die Leistungsdiagnostik. In: Kindermann W, Hort W (Hrsg) Sportmedizin für Breiten- und Leistungssport. Gräfelfing: Demeter S 19

  26. Khanna PK, Seth HN, Balasubramanian V, Hoon RS (1979) Effect of submaximal exercise on fibrinolytic activity in ischemic heart disease. Br Heart J 37:1273

    Google Scholar 

  27. Kernoff PBA, McNicol GP (1977) Normal and abnormal fibrinolysis. Br Med Bull 33:239

    Google Scholar 

  28. Luskutoff DJ, Edgieton TS (1977) Synthesis of a fibrinolytic activator and inhibitor by endothelial cells. Proc Natl Acad Sci USA 74:1903

    Google Scholar 

  29. Mehta J, Mehta P (1982) Comparison of platelet function during exercise in normal subjects and coronary artery disease patients: Potential role of platelet activation in myocardial ischemia. An Heart J

  30. Menon S, Madras MB, Burke F, Dewar HA (1967) Effect of strenuous and graded exercise on fibrinolytic activity. Lancet I:700

    Google Scholar 

  31. Moxley RT, Brackmann P, Astrup T (1970) Resting levels of fibrinolysis in blood in inactive and exercising men. J Appl Physiol 28:549

    Google Scholar 

  32. Mustard JF, Packham MA (1975) The role of blood and platelets in atherosclerosis. Thromb Diath Haemorrh 33:444

    Google Scholar 

  33. Ogston D, Fullerton HW, Aberd MD (1961) Changes in fibrinolytic activity produced by physical activity. Lancet II:730

    Google Scholar 

  34. Poortmans K, Luke H, Zpipursky A, Bienenstock J (1971) Fibrinolytic activity and fibrinogen split products in exercise protein. Clin Chim Acta 35:449

    Google Scholar 

  35. Prentice CRM, Hassenein AA, McNicol GP, Douglas A (1972) Studies on blood coagulation, fibrinolysis and platelet function following exercise in normal and splenectomized people. Br J Haematol 23:541

    Google Scholar 

  36. Rennie JAN, Bennett B, Ogston D (1977) Effect of local exercise and vessels occlusion on fibrinolytic activity. J Clin Pathol 30:350

    Google Scholar 

  37. Röcker L, Schmidt HM, Motz W (1977) Der Einfluß körperlicher Leistungen auf Laboratoriumsbefunde im Blut. Ärztl Lab 23:351

    Google Scholar 

  38. Rosing DR, Brakman P, Redwood DR, Goldstein RE (1970) Blood fibrinolytic activity in man. Circ Res 27:171

    Google Scholar 

  39. Rizza CR (1961) Effect of exercise on the level of antihaemophilic globulin in human blood. J Physiol 156:128

    Google Scholar 

  40. Sarajas HSS (1976) Reactions patterns of blood platelets to exercise. Adv Cardiol 18:176

    Google Scholar 

  41. Sarnoff JG (1969) Alterations in fibrinolysis and blood coagulation. Lancet I:259

    Google Scholar 

  42. Seth HN (1972) Fibrinolytic response to moderate exercise and platelet adhesion in diabetes mellitus. Acta Diabetal Lat 10:306

    Google Scholar 

  43. Shaw DA, McNaughton D (1963) Relationship between blood fibrinolytic activity and body fitness. Lancet I:352

    Google Scholar 

  44. Sherry S, Fletcher AP, Alkjaersig N (1959) Fibrinolysis and fibrinolytic activity in man. Physiol Med 39:343

    Google Scholar 

  45. Sikka KK, Nath K, Samuel KC, Gahlaut DS, Srivastava MC, Gaffar A (1967) Plasma fibrinolytic activity in diabetes mellitus. J Assoc Physicians India 15:279

    Google Scholar 

  46. Simpson MT, Howes CG, Olewine AD, Ramsey FH et al. (1972) Physical activity catecholamines, and platelet stickiness. Recent advances in Studies on Cardiac structure. Metabolism 1:742

    Google Scholar 

  47. Sinha BC, Gosh BP, Misra H (1960) Further studies on inhibition of fibrinolysis in coronary and cerebral thrombosis cases. Indian Heart J 12:197

    Google Scholar 

  48. Wachholder K, Parwitz E, Egli H, Kesseler K (1957) Der Einfluß körperlicher Arbeit auf die Zahl der Thrombozyten und auf deren Haftneigung. Acta Haematol 18:59

    Google Scholar 

  49. Warlow CP, Ogston P (1974) Effect of exercise on platelet count, adhesion, and aggregation. Acta Haematol 52:47

    Google Scholar 

  50. Warren K, Palmer PD, Dennis I, Goldberg MA (1979) Hematological changes during exercise. In: Lowenthal DT, Bherodwaja K, Oaks WM (Hrsg.) Therapeutics through exercise. Grune & Stratton, New York

    Google Scholar 

  51. Williams-Sanders R, Logue E, Lewis JL, Barton T (1980) Stead NW, Wallace AG, Pizzo SV (1980) Physical conditioning augments the fibrinolytic response to venous occlusion in healthy adults. N Engl J Med 18:987

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Diehm, C., Mörl, H. & Schettler, G. Beeinflussung von Blutgerinnung und Fibrinolyse durch körperliche Aktivität. Klin Wochenschr 62, 299–302 (1984). https://doi.org/10.1007/BF01716445

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01716445

Key words

Navigation