Summary
Twenty-seven patients with echocardiographic evidence of primary mitral valve prolapse (MVP) were tested for the presence of joint hypermobility using the criteria of Beighton and Horan. In the examined group, joint hypermobility was found in 14 patients (52%). This occurrence was statistically significant. In patients with simultaneous occurrence of MVP and articular hypermobility we have found a number of pathologic arthrologic manifestations, such as arthralgias, synovitic reactions, distortions, low back pain, and others. In patients with articular hypermobility, there were increased functions of antigen B 35.
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Widimský, P., Sládková, T., Gregor, P., Červenka, V., Víšek, V., Hrdlička, S., Dvořák, J. Syndrom prolapsu mitrální chlopnę. Prakt Lék (Praha), 1984, č. 1, 4–6.
Storožakov, G.I. Prolaps mitral'nogo klapana. Vopr Revmatizma, 1982, 2, 71–75.
Beighton, P., Horan, S. Orthopaedic aspects of the Ehlers-Danlose syndrome. J Bone Joint Surg, 1964, 51 B, 444–453.
Barlow, J.B., Pocock, W.A., Marchand, P., Denny, M. The significance of late systolic murmurs. Am Heart J, 1963, 66, 443.
Procacci, P.M., Savran, V.S., Schreiter, S.L., Bryson, A.L. Prevalence of clinical mitral-valve prolapse in 1169 young women. N Engl J Med, 1976, 294, 20, 1086–1088.
Devereux, B.R., Brown, W.T., Kramer-Fox, R., Sachs, I. Inheritance of mitral valve prolapse. Effect of age and sex on gene expression. Am Intern Med 1982, 97, 6, 826–832.
Olsen, E.G.J., Al-Rufaie, H.K., The floppy mitral valve. Study on pathogenesis. Br Heart J, 1980, 44, 6, 674–683.
Bonella, D., Parker, D.J., Davies, M.J. Accumulation of procollagen in human floppy mitral valves. Lancet, 1980, 880–881.
Beighton, P., Grahame, R., Bird, H. Hypermobility of Joints. Heidelberg, New York, Springer Verlag, 1983, 178.
Kirk, J.A., Ansell, B.M., Bywaters, E.G.L., The Hypermobility syndrome. Musculo-skeletal complaints associated with generalized joint hypermobility. Ann Rheum Dis, 1967, 26, 419.
Grahame, R., Edwards, J.C., Pitcher, D., Gabel, A., Harvey, W.A. A clinical and echocardiographic study of patients with the hypermobility syndrome. Ann Rheum Dis, 1981, 40, 541–546.
Pitcher, D., Grahame, R. Mitral valve prolapse and joint hypermobility: evidence for a systemic connective tissue abnormality. Ann Rheum Dis, 1982, 41, 352–354.
Durlach, J., Henrotte, J.G., Lepage, V., Elchidial, A., Degos, L. HLA-B35 Antigen, mitral valve prolapse and blood magnesium level. In: Magnesium Deficiency. III. Cardiovascular Disease. First Eur. Congr. Magnesium, Lisabon, 1983, 95–101, Karger, Basel 1985.
Nyulassy, Š., Hirschová, V., Buc, M., Silvánová, E., Štefanovič, J. Sledovanie HLA systému v slovenskej populácií. Frekvencia antigénov A, B, C lokusu, Bratisl. lek. Listy, 1977, 68, 4, 436–444.
Reisenauer, R. Metody matematické statistiky. Red. I. Bergerová, 2. vyd., Praha, SNTL 1970, 240.
Ondrašík, M., Rybár, I., Sit'aj, Š., Buran, I. Sustavnaja gipermobil'nost' v slovackoj popul'jacii, Revmatologija, 1986, 2, 24–26.
Ondrašík, M., Rybár, I., Bošmanský, K. Primary mitral valve prolapse and articular hypermobility, Abstracts of XIth European Congress of Rheumatology, Athens, 1987, 245.
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Ondrašík, M., Rybár, I., Rus, V. et al. Joint hypermobility in primary mitral valve prolapse patients. Clin Rheumatol 7, 69–73 (1988). https://doi.org/10.1007/BF02284059
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DOI: https://doi.org/10.1007/BF02284059