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Does corticosteroid usage in rhinoplasty cause mood changes?

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Abstract

In this study, the psychological effects of single-dose corticosteroids administered to patients who had undergone rhinoplasty were assessed. A total of 30 rhinoplasty patients were included in the study and were randomly assigned to 1 of 2 groups. Preoperatively, patients completed the Bech Rafaelsen Mania Scale and the Beck Depression Inventory. Dexamethasone 10 mg was given intravenously just before surgery to the first group, but no medication was administered to the second group. On the first postoperative day, patients were seen again, and the Bech Rafaelsen Mania Scale and the Beck Depression Inventory were again completed. Periorbital edema and ecchymosis were graded, and psychological well-being was measured on a standard visual analog scale. All patients and physicians were blinded to treatment until the end of the study. Results show that administration of a single-dose of dexamethasone 10 mg caused neither euphoria nor depression. No significant differences were observed between steroid and control groups in terms of patients’ psychological well-being. With single-dose dexamethasone, periorbital edema was significantly reduced on the first 2 postoperative days, and upper eyelid ecchymosis was significantly decreased only on the first postoperative day. However, preoperative steroid administration had no influence on ecchymosis of the lower eyelid. The authors conclude that single-dose dexamethasone 10 mg can be used safely to reduce periorbital edema and ecchymosis in rhinoplasty patients.

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References

  1. Kara CO, Gokalan I. Effects of single dose steroid usage on edema, ecchymosis and intraoperative bleeding in rhinoplasty.Plast Reconstr Surg. 1999; 104: 2213–2218.

    Article  PubMed  CAS  Google Scholar 

  2. Griffies WS, Kennedy K, Gasser C, Fankhauser C, Taylor R. Steroids in rhinoplasty.Laryngoscope. 1989; 99: 1161–1164.

    Article  PubMed  CAS  Google Scholar 

  3. Habal MB. Prevention of postoperative facial edema with steroids after facial surgery.Aesth Plast Surg. 1985; 9: 69–71.

    Article  CAS  Google Scholar 

  4. Hoffmann DF, Cook TA, Quatela VC, Wang TD, Brownrigg PJ, Brummett RE. Steroids and rhinoplasty: a double-blind study.Arch Otolaryngol Head Neck Surg. 1991; 117: 990–993.

    PubMed  CAS  Google Scholar 

  5. Kara CO, Kara IG, Topuz B. Does creating a subperiosteal tunnel influence the periorbital edema and ecchymosis in rhinoplasty?J Oral Maxillofac Surg. 2005; 63: 1088–1090.

    Article  PubMed  Google Scholar 

  6. Kara CO, Kara IG, Yaylali V. Subconjunctival ecchymosis due to rhinoplasty.Rhinology. 2001; 39: 166–168.

    PubMed  CAS  Google Scholar 

  7. Kargi E, Hosnuter M, Babuccu O, Altunkaya H, Altinyazar C. Effect of steroids on edema, ecchymosis, and intraoperative bleeding in rhinoplasty.Ann Plastic Surg. 2003; 51: 570–574.

    Article  Google Scholar 

  8. Kaschke O. Postoperative care and management. In: Behrbohm H, Tardy ME Jr, eds.Essentials of Septorhinoplasty. Stuttgart: Georg Thieme Verlag; 2004: 234–236.

    Google Scholar 

  9. McCharthy JG, Wood-Smith D. Rhinoplasty. In: McCharthy JG, ed.Plastic Surgery. Philadelphia, Pa: WB Saunders; 1990: 1785–1894.

    Google Scholar 

  10. Tebbet JB.Primary Rhinoplasty. St Louis, Mo: Mosby; 2000.

    Google Scholar 

  11. Echavez MI, Mangat DS. Effects of steroids on mood, edema, and ecchymosis in facial plastic surgery.Arch Otolaryngol. 1994; 120: 1137–1141.

    CAS  Google Scholar 

  12. First MB, Spitzer RL, Gibbon M, Williams JBW.Structured Clinical Interview for DSM-IV Clinical Version (SCID-I/CV). Washington, DC: American Psychiatric Press; 1997.

    Google Scholar 

  13. Bech P, Bolwing TG, Kramp P, Rafaelson OJ. The Bech-Rafaelson Mania Scale and the Hamilton Depression Scale: evaluation of homogeneity and inter-observer reliability.Acta Psychiatr Scand. 1979; 59: 420–430.

    Article  PubMed  CAS  Google Scholar 

  14. Beck AT. An inventory for measuring depression.Arch Gen Psychiatry. 1961; 4: 561–571.

    PubMed  CAS  Google Scholar 

  15. Owsley JQ, Weibel TJ, Adams WA. Does steroid medication reduce facial edema following face lift surgery? A prospective, randomized study of 30 consecutive patients.Plast Reconstr Surg. 1996; 98: 1–6.

    Article  PubMed  CAS  Google Scholar 

  16. Schimer BP, Parker KL. Adrenocorticotropic hormone, adrenocortical steroids and their synthetic analogs, inhibitors of the synthesis and actions of adrenocortical hormones. In: Hardman JG, Limbird EL, Molinoff PB, Gilman AG, eds.Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 9th ed. New York, NY: McGraw-Hill; 1996: 1442–1454.

    Google Scholar 

  17. Cawson RA, James J. Adrenal crisis in a dental patient having systemic corticosteroids.Br J Oral Surg. 1973; 10: 305–309.

    Article  PubMed  CAS  Google Scholar 

  18. Brown ES, Khan DA, Nejtek VA. The psychiatric side effects of corticosteroids.Ann Allergy Asthma Immunol. 1999; 83: 495–503.

    Article  PubMed  CAS  Google Scholar 

  19. Brown ES, Suppes T. Mood symptoms during corticosteroid therapy: a review.Harv Rev Psychiatry. 1998; 5: 239–246.

    Article  PubMed  CAS  Google Scholar 

  20. Patten SB, Williams JV, Love EJ. A case-control study of corticosteroid exposure as a risk factor for clinically diagnosed depressive disorders in a hospitalized population.Can J Psychiatry. 1995; 40: 396–400.

    PubMed  CAS  Google Scholar 

  21. Lewis DA, Smith RE. Steroid-induced psychiatric syndromes: a report of 14 cases and a review of the literature.J Affect Disord. 1983; 5: 319–332.

    Article  PubMed  CAS  Google Scholar 

  22. Klein JF. Adverse psychiatric effects of systemic glucocorticoid therapy.Am Fam Physician. 1992; 46: 1469–1474.

    PubMed  CAS  Google Scholar 

  23. Assimes TL, Lessard ML. The use of perioperative corticosteroids in craniomaxillofacial surgery.Plast Reconstr Surg. 1999; 103: 313–321.

    Article  PubMed  CAS  Google Scholar 

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Ozdel, O., Kara, C.O., Kara, I.G. et al. Does corticosteroid usage in rhinoplasty cause mood changes?. Adv Therapy 23, 809–816 (2006). https://doi.org/10.1007/BF02850322

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