Abstract.
The exudation of neutrophils is the hallmark of a form of inflammatory response occurring after tissue colonization by invading bacteria or as an expression of various non-infectious diseases. All these diseases are characterized by a high risk of developing irreversible tissue injury. Neutrophil-endothelium interactions, activation-induced functional and structural changes of responding neutrophils, regulatory systems of neutrophil function, and oxidative-proteolytic pathways responsible for histotoxicity are reviewed here. Finally, perspectives for rational approaches to handle the development of tissue injury during neutrophilic inflammation are considered.
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Received 14 April 1997; returned for revision 5 June 1997; accepted by M. J. Parnham 30 June 1997
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Dallegri, F., Ottonello, L. Tissue injury in neutrophilic inflammation. Inflamm. res. 46, 382–391 (1997). https://doi.org/10.1007/s000110050208
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DOI: https://doi.org/10.1007/s000110050208