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Mesenchymal stem cell-based therapy for cartilage repair: a review

  • Knee
  • Published:
Knee Surgery, Sports Traumatology, Arthroscopy Aims and scope

Abstract

Articular cartilage injury remains one of the major concerns in orthopaedic surgery. Mesenchymal stem cell (MSC) transplantation has been introduced to avoid some of the side effects and complications of current techniques. The purpose of this paper is to review the literature on MSC-based cell therapy for articular cartilage repair to determine if it can be an alternative treatment for cartilage injury. MSCs retain both high proliferative potential and multipotentiality, including chondrogenic differentiation potential, and a number of successful results in transplantation of MSCs into cartilage defects have been reported in animal studies. However, the use of MSCs for cartilage repair is still at the stage of preclinical and phase I studies, and no comparative clinical studies have been reported. Therefore, it is difficult to make conclusions in human studies. This requires randomized clinical trials to evaluate the effectiveness of MSC-based cell therapy for cartilage repair.

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Acknowledgment

H.K. was supported by a grant from Research Fund of Mitsukoshi Health and Welfare Foundation 2007.

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Authors and Affiliations

  1. Oslo Sports Trauma Research Center, Norwegian School of Sports Sciences, PO Box 4014, Ullevaal Stadion, 0806, Oslo, Norway

    Hideyuki Koga & Lars Engebretsen

  2. Orthopaedic Center, Ullevaal University Hospital, 0407, Oslo, Norway

    Lars Engebretsen

  3. Faculty of Medicine, University of Oslo, 0407, Oslo, Norway

    Lars Engebretsen

  4. Laboratory for Cell Therapy, Institute of Immunology, Rikshospitalet University Hospital, 0027, Oslo, Norway

    Jan E. Brinchmann

  5. Section of Orthopaedic Surgery, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan

    Takeshi Muneta

  6. Section of Cartilage Regeneration, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan

    Ichiro Sekiya

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  1. Hideyuki Koga
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  2. Lars Engebretsen
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  3. Jan E. Brinchmann
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  4. Takeshi Muneta
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  5. Ichiro Sekiya
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Correspondence to Hideyuki Koga.

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Koga, H., Engebretsen, L., Brinchmann, J.E. et al. Mesenchymal stem cell-based therapy for cartilage repair: a review. Knee Surg Sports Traumatol Arthrosc 17, 1289–1297 (2009). https://doi.org/10.1007/s00167-009-0782-4

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