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Regulation of vascular development by fibroblast growth factors

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Abstract

Fibroblast growth factors (FGFs) are potent stimulators of angiogenesis in vitro and in vivo. However, the precise role of FGFs and vascular development in normal and pathological tissue has long remained ill defined. Recently, substantial progress has been made toward a better understanding of their role. Genetic studies in mice or in culture systems indicate a role for FGFs in vessel assembly and sprouting. FGFs also stimulate blood vessel branching and lymphangiogenesis. The molecular mechanisms by which FGFs mediate angiogenesis are also better understood. Finally, the FGF/FGF-receptor system has become a focus for the development of novel therapeutic strategies for the treatment of angiogenesis-related diseases such as tissue ischemia.

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Acknowledgements

The authors thank Dr. Thomas Durkin (University Bordeaux I) for critically reading the manuscript. Space constraints have meant that we could not quote all the relevant literature, and we apologize to those authors whose work is not mentioned.

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Correspondence to Andreas Bikfalvi.

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Work described herein from our laboratory was supported by grants from the Ligue Nationale contre le Cancer, the Association de la Recherche sur le Cancer, Rétina France, the Institut National de la Santé et de la Recherche Médicale (INSERM), and the Ministère de la Recherche

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Auguste, P., Javerzat, S. & Bikfalvi, A. Regulation of vascular development by fibroblast growth factors. Cell Tissue Res 314, 157–166 (2003). https://doi.org/10.1007/s00441-003-0750-0

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