Abstract
Discography is the only available method of directly challenging the discs for pain sensitivity. However, it is invasive, expensive and there is a debate about its clinical value. There is a need to identify clinical signs that may indicate the need for a discography examination. Pain centralization (retreat of referred pain to towards the spinal midline) has been associated with positive discography and possesses specificity between 80 and 100% depending on levels of disablement and psychosocial distress. Less than half of positive discography patients reports centralization and there is a need to identify other potentially valuable predictors. This study estimated the diagnostic accuracy of clinical variables in relation to provocation discography. In a blinded, prospective reference standard design in a private interventional radiology clinic, chronic low back patients received a detailed clinical examination followed by discography. Patients were typically disabled with high levels of psychosocial distress. Logistic regression modelling identified potentially useful clinical variables, and sensitivity, specificity and likelihood ratios were calculated for promising specific variables and combinations of variables. Of 118 consecutive discography cases, 107 had unconfounded data on discography results. History of persistent pain between acute episodes, a significant loss of extension and a subjective report of ‘vulnerability’ in what is termed as the ‘neutral zone’ had specificities of 83–92% and likelihood ratios between 2.0 and 4.1. Two combinations of variables were highly specific to positive discography, but no suitable screening test useful for ruling out positive discography was established. Three clinical variables have modest predictive power in relation to lumbar discography results and two combinations of variables were highly specific to positive discography.
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Acknowledgements
This projected was supported by grants from: The International Spine Injection Society. The New Zealand Society of Physiotherapists Scholarship Fund. The New Zealand Manipulative Physiotherapists Education Trust Fund. Thanks to Sharon B Young PT for examining ten patients.
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Financial interest statement: No financial relationship exists between the subject matter and any of the authors. Participation: Concept and research design were provided by Dr Laslett, Dr Aprill and Prof Öberg. Project management was done by Dr Laslett. Facilities and equipment were provided by Dr Aprill. Writing was done by Dr Laslett, Prof Öberg and Dr McDonald. Data analysis and statistical support were provided by Dr McDonald. The study was carried out at Magnolia Diagnostics, New Orleans, LA, USA. Reprints will not be available.
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Laslett, M., Aprill, C.N., McDonald, B. et al. Clinical predictors of lumbar provocation discography: a study of clinical predictors of lumbar provocation discography. Eur Spine J 15, 1473–1484 (2006). https://doi.org/10.1007/s00586-006-0062-7
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DOI: https://doi.org/10.1007/s00586-006-0062-7